| Literature DB >> 1647760 |
M Baudry1, G Massicotte, S Hauge.
Abstract
We investigated the effects of phospholipids and cholesterol on the binding of [3H]-AMPA to rat telencephalic membranes. Phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and cholesterol were without effect at concentrations up to 1.5 mg/mg protein. Only phosphatidylserine increased [3H]-AMPA binding in a dose-dependent manner. This effect was due to an increase in the affinity of the low affinity component of [3H]-AMPA binding. These results indicate that the distribution of phosphatidylserine in membranes modulates the properties of the AMPA/quisqualate receptor.Entities:
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Year: 1991 PMID： 1647760 DOI： 10.1016/0163-1047(91)80134-z
Source DB: PubMed Journal: Behav Neural Biol ISSN： 0163-1047