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Literature DB >> 16476580

Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.

Jian Chen¹, Li Li, Yuanyuan Zhang, Huirong Yang, Youheng Wei, Lin Zhang, Xianghua Liu, Long Yu.

Abstract

The peptidyl-prolyl isomerase Pin1 is prevalently overexpressed in human cancers and is regarded as a new diagnostic and therapeutic target. Pin1 interacts with several proteins involved in cell cycle events in a phosphorylation-dependent manner. Among them, NIMA (never in mitosis, gene A) was first identified to interact with Pin1. In this report, we found that Pin1 could interact with Nek6, one of the human NIMA-related kinases (Neks). This interaction was confirmed by GST pull-down assay, which was further confirmed by immunoprecipitation experiments, as well as immunofluorescence colocalization. We further studied Pin1 and Nek6 mRNA level in 40 pairs of hepatocellular carcinoma cases, finding significant correlations between Nek6 and Pin1 mRNA expression levels in these samples.

Entities: Disease Gene Species

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Year: 2006 PMID： 16476580 DOI： 10.1016/j.bbrc.2005.12.228

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

19 in total

1. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

Authors: Laura O'Regan; Andrew M Fry
Journal: Mol Cell Biol Date: 2009-05-04 Impact factor: 4.272

2. Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer.

Authors: Xiaolei Cao; Yunfei Xia; Junling Yang; Jinxia Jiang; Li Chen; Runzhou Ni; Liren Li; Zhifeng Gu
Journal: Pathol Oncol Res Date: 2011-07-05 Impact factor: 3.201

10. Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis.

Authors: A Takeno; I Takemasa; Y Doki; M Yamasaki; H Miyata; S Takiguchi; Y Fujiwara; K Matsubara; M Monden
Journal: Br J Cancer Date: 2008-09-30 Impact factor: 7.640

Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients.

1. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

2. Clinical and biological significance of never in mitosis gene A-related kinase 6 (NEK6) expression in hepatic cell cancer.

3. Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.

Review 4. "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases.

Review 5. NIMA-related kinase-6 (NEK6) as an executable target in cancer.

6. Correlation analysis of liver tumor-associated genes with liver regeneration.

7. Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation.

8. Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.

9. Mitotic regulation by NIMA-related kinases.

10. Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis.