| Literature DB >> 16476504 |
Andreas Stang1, Hermann Pohlabeln, Klaus M Müller, Ingeborg Jahn, Klaus Giersiepen, Karl-Heinz Jöckel.
Abstract
Only few studies have compared the agreement of histological lung carcinoma diagnosis of a population-based case series and an independent pathology review. We analyzed data of our population-based lung cancer case-control study to determine the agreement in the histopathological evaluation of lung cancer. Six-hundred and sixty-eight out of 1004 interviewed male and female lung cancer cases were histologically evaluated according to the 1981 WHO classification by regional pathologists and a central pathologist who was blinded to the evaluations of the regional pathologists. The observed agreement was 0.65 with kappa = 0.54 (95% CI: 0.49-0.58). It was highest for small-cell carcinoma (0.94; kappa = 0.82) and lower for squamous-cell carcinoma (0.81; kappa = 0.58) and adenocarcinoma (0.81; kappa = 0.55). Agreement was slightly higher among women than men. The observed agreement among non-smoking cases was 58% as compared to 67% heavy smoking cases. The moderate agreement for squamous-cell and adenocarcinoma complicates epidemiological studies that address these histological subtypes.Entities:
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Year: 2006 PMID： 16476504 DOI： 10.1016/j.lungcan.2005.11.012
Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705