Brian Dean1, Laura Gray, Elizabeth Scarr. 1. The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, The University of Melbourne, Parkville, Victoria, Australia. bdean_mhri@iprimus.com.au
Abstract
OBJECTIVE: To determine if levels of the glial-derived proteins S100beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder. METHOD: Levels of S100beta, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis. RESULTS: Levels of S100beta were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses. CONCLUSIONS: Regionally selective changes in cortical S100beta may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival.
OBJECTIVE: To determine if levels of the glial-derived proteins S100beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder. METHOD: Levels of S100beta, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis. RESULTS: Levels of S100beta were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses. CONCLUSIONS: Regionally selective changes in cortical S100beta may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival.
Authors: Xiaolu Zhang; Rawan S Alnafisah; Abdul-Rizaq A Hamoud; Rammohan Shukla; Robert E McCullumsmith; Sinead M O'Donovan Journal: Adv Neurobiol Date: 2021
Authors: Amy E Steffek; Robert E McCullumsmith; Vahram Haroutunian; James H Meador-Woodruff Journal: Schizophr Res Date: 2008-06-17 Impact factor: 4.939
Authors: Xiaolu Zhang; Rawan S Alnafisah; Abdul-Rizaq A Hamoud; Rammohan Shukla; Zhexing Wen; Robert E McCullumsmith; Sinead M O'Donovan Journal: Neurochem Res Date: 2021-01-07 Impact factor: 4.414