Literature DB >> 16475220

Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata.

Mário Laa Vasconcellos1, Tania Ms Silva, Celso A Camara, Rodrigo M Martins, Kelly M Lacerda, Horacimone M Lopes, Vera Lp Pereira, Rodrigo Oma de Souza, Lívia Tc Crespo.   

Abstract

The molluscicidal activities of ten Baylis-Hillman adducts against Biomphalaria glabrata (Say) snails, the intermediate host of schistosomiasis, have been determined. Nine of these compounds showed significant molluscicidal activity against B. glabrata, falling below the threshold of 100 microg ml(-1) set for potential molluscicidal activity by the World Health Organisation. Among these compounds, 3-hydroxy-2-methylene-3-(4-nitrophenyl)propanenitrile had the highest activity, with LC(50) = 6.64 microg ml(-1).

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Year:  2006        PMID： 16475220     DOI： 10.1002/ps.1153

Source DB:  PubMed          Journal:  Pest Manag Sci        ISSN： 1526-498X            Impact factor:   4.845


  3 in total

1.  Biological activity of Morita-Baylis-Hillman adduct homodimers in L. infantum and L. amazonensis: anti-Leishmania activity and cytotoxicity.

Authors:  Juliana da Câmara Rocha; Klinger Antonio da Franca Rodrigues; Patrícia Lima do Nascimento Néris; Larisse Virgolino da Silva; Fernanda Silva Almeida; Viviane Silva Lima; Rephany Fonseca Peixoto; Juliene da Câmara Rocha; Fátima de Lourdes Assunção Araújo de Azevedo; Robson Cavalcanti Veras; Isac Almeida de Medeiros; Wagner André Vieira da Silva; Claudio G Lima-Junior; Mário Luiz Araújo de Almeida Vasconcellos; Ian Porto Gurgel do Amaral; Márcia Rosa de Oliveira; Tatjana de Souza Lima Keesen
Journal:  Parasitol Res       Date:  2019-08-07       Impact factor: 2.289

2.  Morita-Baylis-Hillman Adduct 2-(3-Hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) Modulates Inflammatory Process In vitro and In vivo.

Authors:  Juliane Santos de França; José Marreiro de Sales-Neto; Deyse Cristina Madruga Carvalho; Éssia de Almeida Lima; Tayná Rodrigues Olegário; Rhuan Karlos Santos Mendes; Claudio Gabriel Lima-Junior; Mário Luiz Araújo de Almeida Vasconcellos; Sandra Rodrigues-Mascarenhas
Journal:  Inflammation       Date:  2020-11-24       Impact factor: 4.657

Review 3.  Molluscicides against the snail-intermediate host of Schistosoma: a review.

Authors:  Lvyin Zheng; Ling Deng; Yumei Zhong; Yatang Wang; Wei Guo; Xiaolin Fan
Journal:  Parasitol Res       Date:  2021-09-06       Impact factor: 2.289
  3 in total

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