Literature DB >> 16474202

Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA expression in U937 cells.

Tomoki Shokawa1, Masao Yoshizumi, Hideya Yamamoto, Shinji Omura, Mamoru Toyofuku, Yoshito Shimizu, Michinori Imazu, Nobuoki Kohno.   

Abstract

Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.

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Year:  2006        PMID： 16474202     DOI： 10.1254/jphs.sc0040188

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  10 in total

1.  Tissue heme oxygenase-1 exerts anti-inflammatory effects on LPS-induced pulmonary inflammation.

Authors:  F M Konrad; U Knausberg; R Höne; K-C Ngamsri; J Reutershan
Journal:  Mucosal Immunol       Date:  2015-05-06       Impact factor: 7.313

Review 2.  Monocyte chemoattractant protein-1 (MCP-1): an overview.

Authors:  Satish L Deshmane; Sergey Kremlev; Shohreh Amini; Bassel E Sawaya
Journal:  J Interferon Cytokine Res       Date:  2009-06       Impact factor: 2.607

3.  GT-repeat polymorphism in the heme oxygenase-1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure.

Authors:  Meei-Maan Wu; Hung-Yi Chiou; Te-Chang Lee; Chi-Ling Chen; Ling-I Hsu; Yuan-Hung Wang; Wen-Ling Huang; Yi-Chen Hsieh; Tse-Yen Yang; Cheng-Yeh Lee; Ping-Keung Yip; Chih-Hao Wang; Yu-Mei Hsueh; Chien-Jen Chen
Journal:  J Biomed Sci       Date:  2010-08-26       Impact factor: 8.410

4.  Literature mining for the discovery of hidden connections between drugs, genes and diseases.

Authors:  Raoul Frijters; Marianne van Vugt; Ruben Smeets; René van Schaik; Jacob de Vlieg; Wynand Alkema
Journal:  PLoS Comput Biol       Date:  2010-09-23       Impact factor: 4.475

5.  Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells.

Authors:  Liliane R Alves; Elaine S Costa; Marcos H F Sorgine; Maria Clara L Nascimento-Silva; Cristina Teodosio; Paloma Bárcena; Hugo C Castro-Faria-Neto; Patrícia T Bozza; Alberto Orfao; Pedro L Oliveira; Clarissa M Maya-Monteiro
Journal:  PLoS One       Date:  2011-07-13       Impact factor: 3.240

6.  Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.

Authors:  Alexandre Chigaev; Yelena Smagley; Larry A Sklar
Journal:  BMC Immunol       Date:  2014-10-31       Impact factor: 3.615

7.  The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet.

Authors:  Natasa Bogavac-Stanojevic; Jelena Kotur Stevuljevic; Darko Cerne; Janja Zupan; Janja Marc; Zorica Vujic; Milkica Crevar-Sakac; Miron Sopic; Jelena Munjas; Miroslav Radenkovic; Zorana Jelic-Ivanovic
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

8.  Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice.

Authors:  Leyi Yao; Yali Hao; Guanmei Wen; Qingzhong Xiao; Penglong Wu; Jinheng Wang; Jinbao Liu
Journal:  Front Pharmacol       Date:  2022-02-24       Impact factor: 5.810

9.  Regulation of Cellular Metabolism and Cytokines by the Medicinal Herb Feverfew in the Human Monocytic THP-1 Cells.

Authors:  Chin-Fu Chen; Chun-Huai Cheng
Journal:  Evid Based Complement Alternat Med       Date:  2007-06-11       Impact factor: 2.629

10.  Sickle Cell Anemia Patients Display an Intricate Cellular and Serum Biomarker Network Highlighted by TCD4+CD69+ Lymphocytes, IL-17/MIP-1β, IL-12/VEGF, and IL-10/IP-10 Axis.

Authors:  Nadja Pinto Garcia; Alexander Leonardo S Júnior; Geyse Adriana S Soares; Thainá Cristina C Costa; Alicia Patrine C Dos Santos; Allyson Guimarães Costa; Andréa Monteiro Tarragô; Rejane Nina Martins; Flávia do Carmo Leão Pontes; Emerson Garcia de Almeida; Erich Vinícius de Paula; Olindo Assis Martins-Filho; Adriana Malheiro
Journal:  J Immunol Res       Date:  2020-01-08       Impact factor: 4.818
  10 in total

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