OBJECTIVE: The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients. METHODS:Sixteen outpatients with major depression were treated in a 10-week double-blind trial. Response was defined as a score on the Hamilton Depression Rating Scale (24-item) of less than 10. RESULTS: An accelerated response was observed by week 3 in five subjects receiving citalopram (CIT)+methylphenidate (MPH) and in none of those receiving CIT+placebo (PBO). Subjects receiving citalopram and methylphenidate showed a significant improvement in depressive symptoms compared with those on citalopram and placebo. CONCLUSION: Combined treatment with citalopram and methylphenidate appears to be a viable strategy for accelerating and enhancing antidepressant response in elderly depressed patients limited by tolerability and safety.
RCT Entities:
OBJECTIVE: The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressedpatients. METHODS: Sixteen outpatients with major depression were treated in a 10-week double-blind trial. Response was defined as a score on the Hamilton Depression Rating Scale (24-item) of less than 10. RESULTS: An accelerated response was observed by week 3 in five subjects receiving citalopram (CIT)+methylphenidate (MPH) and in none of those receiving CIT+placebo (PBO). Subjects receiving citalopram and methylphenidate showed a significant improvement in depressive symptoms compared with those on citalopram and placebo. CONCLUSION: Combined treatment with citalopram and methylphenidate appears to be a viable strategy for accelerating and enhancing antidepressant response in elderly depressedpatients limited by tolerability and safety.
Authors: Harris A Eyre; Ascia Eskin; Stanley F Nelson; Natalie M St Cyr; Prabha Siddarth; Bernhard T Baune; Helen Lavretsky Journal: Int J Geriatr Psychiatry Date: 2015-10-15 Impact factor: 3.485
Authors: Rachael W Taylor; Lindsey Marwood; Emanuella Oprea; Valeria DeAngel; Sarah Mather; Beatrice Valentini; Roland Zahn; Allan H Young; Anthony J Cleare Journal: Int J Neuropsychopharmacol Date: 2020-12-03 Impact factor: 5.176
Authors: Shuang Liu; Congxiang Zha; Kassoum Nacro; Min Hu; Wenge Cui; Yuh-Lin Yang; Ulhas Bhatt; Aruna Sambandam; Matthew Isherwood; Larry Yet; Michael T Herr; Sarah Ebeltoft; Carla Hassler; Linda Fleming; Anthony D Pechulis; Anne Payen-Fornicola; Nicholas Holman; Dennis Milanowski; Ian Cotterill; Vadim Mozhaev; Yuri Khmelnitsky; Peter R Guzzo; Bruce J Sargent; Bruce F Molino; Richard Olson; Dalton King; Snjezana Lelas; Yu-Wen Li; Kim Johnson; Thaddeus Molski; Anitra Orie; Alicia Ng; Roy Haskell; Wendy Clarke; Robert Bertekap; Jonathan O'Connell; Nicholas Lodge; Michael Sinz; Stephen Adams; Robert Zaczek; John E Macor Journal: ACS Med Chem Lett Date: 2014-05-13 Impact factor: 4.345