OBJECTIVE: This analysis examined whether patients with Alzheimer disease (AD) tolerate continuous positive airway pressure (CPAP). METHOD:Thirty patients with AD were randomized to CPAP or sham CPAP and completed sleep, depression, and quality-of-life questionnaires. Participants could choose to continue treatment after the trial. RESULTS: Patients wore CPAP for 4.8 hours per night. More depressive symptoms were associated with worse adherence (rS=-0.37; N=30, p<0.04). Patients who continued using CPAP had fewer depressive symptoms (t [19]=2.45, p=0.02) and better adherence (t [19]=2.32, p=0.03) during the trial. CONCLUSION:Patients with AD with obstructive sleep apnea can tolerate CPAP. Adherence and long-term use may be more difficult among those patients with more depressive symptoms.
RCT Entities:
OBJECTIVE: This analysis examined whether patients with Alzheimer disease (AD) tolerate continuous positive airway pressure (CPAP). METHOD: Thirty patients with AD were randomized to CPAP or sham CPAP and completed sleep, depression, and quality-of-life questionnaires. Participants could choose to continue treatment after the trial. RESULTS:Patients wore CPAP for 4.8 hours per night. More depressive symptoms were associated with worse adherence (rS=-0.37; N=30, p<0.04). Patients who continued using CPAP had fewer depressive symptoms (t [19]=2.45, p=0.02) and better adherence (t [19]=2.32, p=0.03) during the trial. CONCLUSION:Patients with AD with obstructive sleep apnea can tolerate CPAP. Adherence and long-term use may be more difficult among those patients with more depressive symptoms.
Authors: Nadia Gosselin; Andrée-Ann Baril; Ricardo S Osorio; Marta Kaminska; Julie Carrier Journal: Am J Respir Crit Care Med Date: 2019-01-15 Impact factor: 21.405
Authors: Bradley F Boeve; Jennifer R Molano; Tanis J Ferman; Siong-Chi Lin; Kevin Bieniek; Maja Tippmann-Peikert; Brendon Boot; Erik K St Louis; David S Knopman; Ronald C Petersen; Michael H Silber Journal: J Clin Sleep Med Date: 2013-05-15 Impact factor: 4.062
Authors: Jana R Cooke; Liat Ayalon; Barton W Palmer; Jose S Loredo; Jody Corey-Bloom; Loki Natarajan; Lianqi Liu; Sonia Ancoli-Israel Journal: J Clin Sleep Med Date: 2009-08-15 Impact factor: 4.062