| Literature DB >> 16473764 |
Ravinder S Vohra1, Jane E Murphy, John H Walker, Sreenivasan Ponnambalam, Shervanthi Homer-Vanniasinkam.
Abstract
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.Entities:
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Year: 2006 PMID： 16473764 DOI： 10.1016/j.tcm.2005.12.001
Source DB: PubMed Journal: Trends Cardiovasc Med ISSN： 1050-1738 Impact factor: 6.677