| Literature DB >> 16473490 |
B Mallikarjuna Rao1, Arpita Chakraborty, M K Srinivasu, M Lalitha Devi, P Rajender Kumar, K B Chandrasekhar, A K Srinivasan, A S Prasad, J Ramanatham.
Abstract
A novel stability-indicating high-performance liquid chromatographic assay method was developed and validated for docetaxel in the presence of degradation products generated from forced decomposition studies. A gradient HPLC method was developed to separate the drug from the degradation products, using a Hichrom RPB HPLC column. Mixture of water and acetonitrile was used as mobile phase. The flow rate was 1.0 ml/min and the detection was done at 230 nm. Using the above method one can carry out the quantitative estimation of impurity namely DCT-1 and docetaxel. The developed gradient LC method was subsequently validated.Entities:
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Year: 2006 PMID： 16473490 DOI： 10.1016/j.jpba.2006.01.011
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935