| Literature DB >> 16472682 |
Abstract
Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes by means of several distinct pathways. Wnt/Fz activation of the small GTPases Rho and Rac has emerged as a key mechanism that regulates cell polarity and movements during vertebrate gastrulation. In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants.Entities:
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Year: 2006 PMID: 16472682 DOI: 10.1016/S0076-6879(06)06038-1
Source DB: PubMed Journal: Methods Enzymol ISSN: 0076-6879 Impact factor: 1.600