Literature DB >> 16472187

Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology.

K M Pfarr1, A M Hoerauf.   

Abstract

Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has demonstrated the feasibility of this strategy and has provided a new chemotherapeutic tool. Recent research shows that depleting Wolbachia will also lessen pathology, and lessen adverse reactions to traditional antifilarial drugs.

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Year:  2006        PMID： 16472187     DOI： 10.2174/138955706775475984

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  8 in total

1.  Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis.

Authors:  M Kurz; I Iturbe-Ormaetxe; R Jarrott; S L O'Neill; K A Byriel; J L Martin; B Heras
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-01-31

2.  Wolbachia enhance Drosophila stem cell proliferation and target the germline stem cell niche.

Authors:  Eva M Fast; Michelle E Toomey; Kanchana Panaram; Danielle Desjardins; Eric D Kolaczyk; Horacio M Frydman
Journal:  Science       Date:  2011-10-20       Impact factor: 47.728

3.  Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.

Authors:  Andrea Schiefer; Alexander Schmitz; Till F Schäberle; Sabine Specht; Christine Lämmer; Kelly L Johnston; Dmitry G Vassylyev; Gabriele M König; Achim Hoerauf; Kenneth Pfarr
Journal:  J Infect Dis       Date:  2012-05-14       Impact factor: 5.226

4.  Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi.

Authors:  Shilpy Shakya; Preeti Bajpai; Sharad Sharma; Shailja Misra-Bhattacharya
Journal:  Parasitol Res       Date:  2008-01-08       Impact factor: 2.289

5.  Simultaneous genome sequencing of symbionts and their hosts.

Authors:  Sujai Kumar; Mark L Blaxter
Journal:  Symbiosis       Date:  2012-02-15       Impact factor: 2.268

6.  Molecular Analysis of Canine Filaria and Its Wolbachia Endosymbionts in Domestic Dogs Collected from Two Animal University Hospitals in Bangkok Metropolitan Region, Thailand.

Authors:  Hathaithip Satjawongvanit; Atchara Phumee; Sonthaya Tiawsirisup; Sivapong Sungpradit; Narisa Brownell; Padet Siriyasatien; Kanok Preativatanyou
Journal:  Pathogens       Date:  2019-07-29

Review 7.  Of mice, cattle, and humans: the immunology and treatment of river blindness.

Authors:  Judith E Allen; Ohene Adjei; Odile Bain; Achim Hoerauf; Wolfgang H Hoffmann; Benjamin L Makepeace; Hartwig Schulz-Key; Vincent N Tanya; Alexander J Trees; Samuel Wanji; David W Taylor
Journal:  PLoS Negl Trop Dis       Date:  2008-04-30

8.  Quinolone-fused cyclic sulfonamide as a novel benign antifilarial agent.

Authors:  Suprabhat Mukherjee; Nikhilesh Joardar; Shovan Mondal; Andrea Schiefer; Achim Hoerauf; Kenneth Pfarr; Santi P Sinha Babu
Journal:  Sci Rep       Date:  2018-08-13       Impact factor: 4.379
  8 in total

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