Literature DB >> 16472186

Drug Targets for Plasmodium falciparum: a post-genomic review/survey.

Iwei Yeh1, Russ B Altman.   

Abstract

Over 300 million cases of malaria each year cause significant morbidity and mortality. Growing drug-resistance among the Plasmodia that cause malaria motivates the development of additional anti-malarial drugs. This review summarizes the current state of knowledge about potential drug targets for malaria. The recently sequenced malaria genome data clarifies parasite metabolic pathways, and more metabolic targets have been identified.

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Year:  2006        PMID： 16472186     DOI： 10.2174/138955706775475957

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  8 in total

1.  Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

Authors:  Anna C van Brummelen; Kellen L Olszewski; Daniel Wilinski; Manuel Llinás; Abraham I Louw; Lyn-Marie Birkholtz
Journal:  J Biol Chem       Date:  2008-12-10       Impact factor: 5.157

2.  Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

Authors:  Gregory J Crowther; Dhanasekaran Shanmugam; Santiago J Carmona; Maria A Doyle; Christiane Hertz-Fowler; Matthew Berriman; Solomon Nwaka; Stuart A Ralph; David S Roos; Wesley C Van Voorhis; Fernán Agüero
Journal:  PLoS Negl Trop Dis       Date:  2010-08-24

3.  Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets.

Authors:  Reagan M Mogire; Hoseah M Akala; Rosaline W Macharia; Dennis W Juma; Agnes C Cheruiyot; Ben Andagalu; Mathew L Brown; Hany A El-Shemy; Steven G Nyanjom
Journal:  PLoS One       Date:  2017-10-31       Impact factor: 3.240

Review 4.  Structure-based ligand design and the promise held for antiprotozoan drug discovery.

Authors:  William N Hunter
Journal:  J Biol Chem       Date:  2008-12-22       Impact factor: 5.157

5.  Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria.

Authors:  Fourie Joubert; Claudia M Harrison; Riaan J Koegelenberg; Christiaan J Odendaal; Tjaart A P de Beer
Journal:  Malar J       Date:  2009-07-30       Impact factor: 2.979

6.  New insights into the genetic regulation of Plasmodium falciparum obtained by Bayesian modeling.

Authors:  Svetlana Bulashevska; Ezekiel Adebiyi; Benedikt Brors; Roland Eils
Journal:  Gene Regul Syst Bio       Date:  2007-11-29

7.  Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum.

Authors:  Laurent Bréhélin; Isabelle Florent; Olivier Gascuel; Eric Maréchal
Journal:  BMC Genomics       Date:  2010-01-15       Impact factor: 3.969

8.  A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism.

Authors:  Isabelle Florent; Betina M Porcel; Elodie Guillaume; Corinne Da Silva; François Artiguenave; Eric Maréchal; Laurent Bréhélin; Olivier Gascuel; Sébastien Charneau; Patrick Wincker; Philippe Grellier
Journal:  BMC Genomics       Date:  2009-05-19       Impact factor: 3.969
  8 in total

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