Literature DB >> 16470330

Detection of novel Y SNPs provides further insights into Y chromosomal variation in Pakistan.

Aisha Mohyuddin1, Qasim Ayub1, Peter A Underhill2, Chris Tyler-Smith3,4, S Qasim Mehdi5.   

Abstract

Biallelic polymorphisms on the Y chromosome have been extensively used to study the history, evolution, and migration patterns of world populations. In this study we screened 8.5 kb of Y chromosomal DNA for single nucleotide polymorphisms (SNPs) in a panel of 95 male individuals belonging to different haplogroups. Five novel Y-SNPs (PK1-5) were identified, four in the Pakistani sample and one in an African sample. The ancestral state of each SNP was determined in two chimpanzee samples and a variety of Pakistani ethnic groups. In addition to these novel Y-SNPs 77 additional markers on the Y chromosome were analyzed to place the SNPs on the phylogenetic tree of Y chromosomal lineages and to further investigate extant human Y chromosomal variation within Pakistan. BATWING analysis gave an estimate of between 2,500 and 7,300 YBP for population expansion in Pakistan which coincides with the period of the Indus Valley civilizations.

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Year:  2006        PMID： 16470330     DOI： 10.1007/s10038-005-0357-2

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  13 in total

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3.  Y-chromosomal DNA variation in Pakistan.

Authors:  Raheel Qamar; Qasim Ayub; Aisha Mohyuddin; Agnar Helgason; Kehkashan Mazhar; Atika Mansoor; Tatiana Zerjal; Chris Tyler-Smith; S Qasim Mehdi
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Journal:  Am J Hum Genet       Date:  2003-01-17       Impact factor: 11.025

5.  Peopling of three Mediterranean islands (Corsica, Sardinia, and Sicily) inferred by Y-chromosome biallelic variability.

Authors:  P Francalacci; L Morelli; P A Underhill; A S Lillie; G Passarino; A Useli; R Madeddu; G Paoli; S Tofanelli; C M Calò; M E Ghiani; L Varesi; M Memmi; G Vona; A A Lin; P Oefner; L L Cavalli-Sforza
Journal:  Am J Phys Anthropol       Date:  2003-07       Impact factor: 2.868

6.  Genetic structure of human populations.

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Journal:  Science       Date:  2002-12-20       Impact factor: 47.728

7.  Investigation of the Greek ancestry of populations from northern Pakistan.

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Journal:  Hum Genet       Date:  2004-02-25       Impact factor: 4.132

8.  The Eurasian heartland: a continental perspective on Y-chromosome diversity.

Authors:  R S Wells; N Yuldasheva; R Ruzibakiev; P A Underhill; I Evseeva; J Blue-Smith; L Jin; B Su; R Pitchappan; S Shanmugalakshmi; K Balakrishnan; M Read; N M Pearson; T Zerjal; M T Webster; I Zholoshvili; E Jamarjashvili; S Gambarov; B Nikbin; A Dostiev; O Aknazarov; P Zalloua; I Tsoy; M Kitaev; M Mirrakhimov; A Chariev; W F Bodmer
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Authors:  P A Underhill; P Shen; A A Lin; L Jin; G Passarino; W H Yang; E Kauffman; B Bonné-Tamir; J Bertranpetit; P Francalacci; M Ibrahim; T Jenkins; J R Kidd; S Q Mehdi; M T Seielstad; R S Wells; A Piazza; R W Davis; M W Feldman; L L Cavalli-Sforza; P J Oefner
Journal:  Nat Genet       Date:  2000-11       Impact factor: 38.330

10.  Reconstruction of human evolutionary tree using polymorphic autosomal microsatellites.

Authors:  Qasim Ayub; Atika Mansoor; Muhammad Ismail; Shagufta Khaliq; Aisha Mohyuddin; Abdul Hameed; Kehkashan Mazhar; Sadia Rehman; Saima Siddiqi; Myrto Papaioannou; Alberto Piazza; Luigi Luca Cavalli-Sforza; S Qasim Mehdi
Journal:  Am J Phys Anthropol       Date:  2003-11       Impact factor: 2.868
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Journal:  Eur J Hum Genet       Date:  2009-11-04       Impact factor: 4.246

2.  Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation.

Authors:  Simona Fornarino; Maria Pala; Vincenza Battaglia; Ramona Maranta; Alessandro Achilli; Guido Modiano; Antonio Torroni; Ornella Semino; Silvana A Santachiara-Benerecetti
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  2 in total

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