PURPOSE OF REVIEW: The association between thrombosis and malignancy in adults is well known. Children are now surviving malignancies that previously resulted in mortality. Complications, however, occur including thrombosis that result in mortality and morbidity. This review will explore the association in children and discuss the epidemiology and evidence-based diagnosis and treatment of thrombosis in this cohort. RECENT FINDINGS: Thrombin is an important link between malignancy, metastases, and inflammation. The accurate diagnosis of thrombosis in the upper venous system is directly related to the diagnostic technique used. Antithrombotic treatment is challenging owing to higher risks of bleeding, for example, decreased platelet counts, tiffelitis, large vascular tumor, etc. SUMMARY: Thrombosis and malignancy are associated in children. Properly designed studies are urgently required to further define the epidemiology of thrombosis in different malignancies and to find the best way to diagnose and treat thrombosis in children.
PURPOSE OF REVIEW: The association between thrombosis and malignancy in adults is well known. Children are now surviving malignancies that previously resulted in mortality. Complications, however, occur including thrombosis that result in mortality and morbidity. This review will explore the association in children and discuss the epidemiology and evidence-based diagnosis and treatment of thrombosis in this cohort. RECENT FINDINGS:Thrombin is an important link between malignancy, metastases, and inflammation. The accurate diagnosis of thrombosis in the upper venous system is directly related to the diagnostic technique used. Antithrombotic treatment is challenging owing to higher risks of bleeding, for example, decreased platelet counts, tiffelitis, large vascular tumor, etc. SUMMARY:Thrombosis and malignancy are associated in children. Properly designed studies are urgently required to further define the epidemiology of thrombosis in different malignancies and to find the best way to diagnose and treat thrombosis in children.
Authors: Alex J Walker; Matthew J Grainge; Tim R Card; Joe West; Susanna Ranta; Jonas F Ludvigsson Journal: Thromb Res Date: 2013-12-21 Impact factor: 3.944
Authors: Irene L M Klaassen; Mandy N Lauw; Marianne D van de Wetering; Bart J Biemond; Saskia Middeldorp; Floor C H Abbink; Marc Bierings; D Maroeska M W Te Loo; Rob Pieters; Inge M van der Sluis; Wim J E Tissing; C Michel Zwaan; C Heleen van Ommen Journal: BMC Pediatr Date: 2017-05-10 Impact factor: 2.125
Authors: Jacqueline Halton; Kim Nagel; Leonardo R Brandão; Mariana Silva; Paul Gibson; Anthony Chan; Kay Blyth; Kim Hicks; Nagina Parmar; Leslie Paddock; Stephanie Willing; Lehana Thabane; Uma Athale Journal: BMC Cancer Date: 2012-07-26 Impact factor: 4.430