Literature DB >> 16470130

Variability in the P6gag domains of HIV-1 involved in viral budding.

Africa Holguín1, Amparo Alvarez, Vincent Soriano.   

Abstract

The genetic variability within PT/SAP, LYP and LXXLF HIV-1 P6gag motifs, required for the binding to Tsg101 and AIP1 cellular host proteins during viral budding, was examined in 122 HIV-infected subjects. PT/SAP duplications were statistically more frequent in B versus non-B subtypes. Substitutions at LYP were fourfold less frequent in antiretroviral-experienced only in clade B. P6gag variability across HIV-1 subtypes and after antiretroviral exposure may influence interactions with host cells involved in viral budding.

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Year:  2006        PMID： 16470130     DOI： 10.1097/01.aids.0000210619.75707.21

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  6 in total

1.  Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain.

Authors:  Angelica N Martins; Abdul A Waheed; Sherimay D Ablan; Wei Huang; Alicia Newton; Christos J Petropoulos; Rodrigo D M Brindeiro; Eric O Freed
Journal:  J Virol       Date:  2015-10-28       Impact factor: 5.103

2.  An integrative bioinformatic approach for studying escape mutations in human immunodeficiency virus type 1 gag in the Pumwani Sex Worker Cohort.

Authors:  Harold O Peters; Mark G Mendoza; Rupert E Capina; Ma Luo; Xiaojuan Mao; Michael Gubbins; Nico J D Nagelkerke; Ian Macarthur; Brent B Sheardown; Joshua Kimani; Charles Wachihi; Subo Thavaneswaran; Francis A Plummer
Journal:  J Virol       Date:  2007-12-05       Impact factor: 5.103

3.  The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa.

Authors:  Shilpee Sharma; Shambhu G Aralaguppe; Melissa-Rose Abrahams; Carolyn Williamson; Clive Gray; Pachamuthu Balakrishnan; Shanmugam Saravanan; Kailapuri G Murugavel; Suniti Solomon; Udaykumar Ranga
Journal:  BMC Infect Dis       Date:  2017-01-24       Impact factor: 3.090

4.  Genetic Diversity and Low Therapeutic Impact of Variant-Specific Markers in HIV-1 Pol Proteins.

Authors:  Paloma Troyano-Hernáez; Roberto Reinosa; Africa Holguín
Journal:  Front Microbiol       Date:  2022-07-14       Impact factor: 6.064

Review 5.  Human Immunodeficiency Virus Gag and protease: partners in resistance.

Authors:  Axel Fun; Annemarie M J Wensing; Jens Verheyen; Monique Nijhuis
Journal:  Retrovirology       Date:  2012-08-06       Impact factor: 4.602

6.  New findings in cleavage sites variability across groups, subtypes and recombinants of human immunodeficiency virus type 1.

Authors:  Esther Torrecilla; Teresa Llácer Delicado; África Holguín
Journal:  PLoS One       Date:  2014-02-07       Impact factor: 3.240
  6 in total

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