| Literature DB >> 16469690 |
Abstract
In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.Entities:
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Year: 2006 PMID： 16469690 DOI： 10.1016/j.cell.2006.01.022
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582