Literature DB >> 1646908

C-myc as an inducer of polycystic kidney disease in transgenic mice.

M Trudel1, V D'Agati, F Costantini.   

Abstract

In this study, a genetic model of polycystic kidney disease (PKD) has been produced in transgenic mice bearing the murine c-myc gene driven by the SV40 enhancer and the adult beta-globin promoter. These animals reproducibly develop PKD and die of renal failure. The phenotype appears to result from the overexpression of c-myc in the renal tubular epithelium and consequent abnormal cell proliferation. These transgenic mice represent a genetic model of PKD which bears similarities to human autosomal dominant PKD (ADPKD) with respect to renal morphology, renal functional alterations and dominant transmission. Study of these transgenic mice may offer valuable insights into the pathogenesis of PKD.

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Year:  1991        PMID： 1646908     DOI： 10.1038/ki.1991.80

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  67 in total

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Journal:  Genes Dev       Date:  1997-08-01       Impact factor: 11.361

2.  The molecular basis of nephrogenesis and congenital kidney disease.

Authors:  J Bard
Journal:  Arch Dis Child       Date:  1992-08       Impact factor: 3.791

3.  FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.

Authors:  Boyi Gan; Carol Lim; Gerald Chu; Sujun Hua; Zhihu Ding; Michael Collins; Jian Hu; Shan Jiang; Eliot Fletcher-Sananikone; Li Zhuang; Michelle Chang; Hongwu Zheng; Y Alan Wang; David J Kwiatkowski; William G Kaelin; Sabina Signoretti; Ronald A DePinho
Journal:  Cancer Cell       Date:  2010-11-16       Impact factor: 31.743

4.  Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.

Authors:  Xia Zhou; Lucy X Fan; Dorien J M Peters; Marie Trudel; James E Bradner; Xiaogang Li
Journal:  Hum Mol Genet       Date:  2015-04-15       Impact factor: 6.150

Review 5.  The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.

Authors:  Tamina Seeger-Nukpezah; Daniel M Geynisman; Anna S Nikonova; Thomas Benzing; Erica A Golemis
Journal:  Nat Rev Nephrol       Date:  2015-04-14       Impact factor: 28.314

6.  Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells.

Authors:  A Geick; P Redecker; A Ehrhardt; R Klocke; D Paul; R Halter
Journal:  Transgenic Res       Date:  2001-12       Impact factor: 2.788

Review 7.  ADPKD: molecular characterization and quest for treatment.

Authors:  Shigeo Horie
Journal:  Clin Exp Nephrol       Date:  2005-12       Impact factor: 2.801

8.  Pkd1 transgenic mice: adult model of polycystic kidney disease with extrarenal and renal phenotypes.

Authors:  Almira Kurbegovic; Olivier Côté; Martin Couillard; Christopher J Ward; Peter C Harris; Marie Trudel
Journal:  Hum Mol Genet       Date:  2010-01-06       Impact factor: 6.150

9.  Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.

Authors:  Jens Nürnberger; Robert L Bacallao; Carrie L Phillips
Journal:  Mol Biol Cell       Date:  2002-09       Impact factor: 4.138

10.  Disappearance of polycystic kidney disease in revertant c-myc transgenic mice.

Authors:  M Trudel; N Chrétien; V D'Agati
Journal:  Mamm Genome       Date:  1994-03       Impact factor: 2.957
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