Literature DB >> 1646687

Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1) in vitro.

K Hirabayashi1, S Iwata, H Matsumoto, T Mori, S Shibata, M Baba, M Ito, S Shigeta, H Nakashima, N Yamamoto.   

Abstract

Chemically modified compounds of glycyrrhizin have been synthesized and evaluated for their inhibitory effect on the replication of human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). Among them, the 11-deoxo compound having a heteroannular diene structure at the C and D rings proved as active against HIV-1 as glycyrrhizin in MT-4 and MOLT-4 cells. It completely inhibited HIV-1-induced cytopathogenicity in both cell lines at a concentration of 0.16 mM. The compound was also effective against HSV-1 with a 50% inhibitory concentration of 0.5 mM [corrected].

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Year:  1991        PMID： 1646687     DOI： 10.1248/cpb.39.112

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  15 in total

1.  In vitro studies on protective effect of Glycyrrhiza glabra root extracts against cadmium-induced genetic and oxidative damage in human lymphocytes.

Authors:  Ebubekir Dirican; Hasan Turkez
Journal:  Cytotechnology       Date:  2013-01-17       Impact factor: 2.058

2.  In vitro and in vivo evaluation of the enhancing activity of glycyrrhizin on the intestinal absorption of drugs.

Authors:  T Imai; M Sakai; H Ohtake; H Azuma; M Otagiri
Journal:  Pharm Res       Date:  1999-01       Impact factor: 4.200

3.  Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines: Anti-tumor and immune activation activities.

Authors:  W T Chung; S H Lee; J D Kim; N S Sung; B Hwang; S Y Lee; C Y Yu; H Y Lee
Journal:  Cytotechnology       Date:  2001-09       Impact factor: 2.058

4.  Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice.

Authors:  Xiao-Lan Li; Ai-Guo Zhou; Li Zhang; Wei-Jun Chen
Journal:  Int J Mol Sci       Date:  2011-01-26       Impact factor: 5.923

5.  The Effect of Aqueous Extract of Glycyrrhiza glabra on Herpes Simplex Virus 1.

Authors:  Masoud Sabouri Ghannad; Avid Mohammadi; Sohayla Safiallahy; Javad Faradmal; Mona Azizi; Zohreh Ahmadvand
Journal:  Jundishapur J Microbiol       Date:  2014-07-01       Impact factor: 0.747

6.  Using glycyrrhizic acid to target sumoylation processes during Epstein-Barr virus latency.

Authors:  Gretchen L Bentz; Angela J Lowrey; Dustin C Horne; Vy Nguyen; Austin R Satterfield; Tabithia D Ross; Abigail E Harrod; Olga N Uchakina; Robert J McKallip
Journal:  PLoS One       Date:  2019-05-24       Impact factor: 3.240

Review 7.  Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.

Authors:  Sulong Xiao; Zhenyu Tian; Yufei Wang; Longlong Si; Lihe Zhang; Demin Zhou
Journal:  Med Res Rev       Date:  2018-01-19       Impact factor: 12.944

Review 8.  Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice.

Authors:  Changchao Huan; Yao Xu; Wei Zhang; Tingting Guo; Haochun Pan; Song Gao
Journal:  Front Pharmacol       Date:  2021-07-06       Impact factor: 5.810

9.  Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.

Authors:  Kosuri Kalyan Chakravarthi; Ramakrishna Avadhani
Journal:  J Nat Sci Biol Med       Date:  2013-07

10.  Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line.

Authors:  Sachiko Matsui; Hiroatsu Matsumoto; Yoshiko Sonoda; Kumi Ando; Eriko Aizu-Yokota; Toshitsugu Sato; Tadashi Kasahara
Journal:  Int Immunopharmacol       Date:  2004-12-15       Impact factor: 4.932
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