INTRODUCTION: Chromosome alterations are associated with esophageal atresia (EA) in up to 11% of the cases. The morbidity and mortality index of this population is different from other EA patients. The present study was aimed to determine the characteristics of this association in a Mexican infant patient population. MATERIAL AND METHODS: Observational, descriptive, retrospective, transversal assay including patients with AE and chromosome alterations over a 31-year period. Gestational age, admittance age, sex, type of atresia, chromosome alteration, additional malformations, treatment, evolution and death cause, were registered. RESULTS: Seventeen patients (4.61%) out of 368 with EA were included. Chromosome 21 trisomy was detected in 12 children and 5 with 18 trisomy. One to 3 additional malformations were found in 16 patients. Fifteen children were subjected to surgical procedures for EA, and 6 for associated malformations. Fourteen children died in a 140-day follow-up period. CONCLUSIONS: Coexistence between AE, trisomys and major malformations was characterized by multifactorial complications which determined adverse evolution in the short term.
INTRODUCTION: Chromosome alterations are associated with esophageal atresia (EA) in up to 11% of the cases. The morbidity and mortality index of this population is different from other EA patients. The present study was aimed to determine the characteristics of this association in a Mexican infantpatient population. MATERIAL AND METHODS: Observational, descriptive, retrospective, transversal assay including patients with AE and chromosome alterations over a 31-year period. Gestational age, admittance age, sex, type of atresia, chromosome alteration, additional malformations, treatment, evolution and death cause, were registered. RESULTS: Seventeen patients (4.61%) out of 368 with EA were included. Chromosome 21 trisomy was detected in 12 children and 5 with 18 trisomy. One to 3 additional malformations were found in 16 patients. Fifteen children were subjected to surgical procedures for EA, and 6 for associated malformations. Fourteen children died in a 140-day follow-up period. CONCLUSIONS: Coexistence between AE, trisomys and major malformations was characterized by multifactorial complications which determined adverse evolution in the short term.
Authors: Andrea Surányi; Tamás Bitó; György Vajda; László Kaiser; Gábor Gáspár; Márta Katona; János Szabó; Attila Pál Journal: Pathol Oncol Res Date: 2008-06-25 Impact factor: 3.201