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Literature DB >> 16465473

Can the passive elasticity of muscle be explained directly from the mechanics of individual titin molecules?

Larissa Tskhovrebova¹, Ahmed Houmeida, John Trinick.

Abstract

Recent progress in understanding the role of titin/connectin in muscle elasticity has been heavily based on results from single molecule mechanical experiments. The shape of force-extension curves from such data is similar to curves from muscle fibres and it has been tempting to assume that muscle elasticity can be extrapolated directly from the single molecule data. In this paper we discuss some of the factors that act on titin in the sarcomere that are likely to preclude such a direct extrapolation.

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Year: 2005 PMID： 16465473 DOI： 10.1007/s10974-005-9034-5

Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698

43 in total

1. Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.

Authors: Kan Ma; Kuan Wang
Journal: FEBS Lett Date: 2002-12-18 Impact factor: 4.124

2. PEVK domain of titin: an entropic spring with actin-binding properties.

Authors: Wolfgang A Linke; Michael Kulke; Hongbin Li; Setsuko Fujita-Becker; Ciprian Neagoe; Dietmar J Manstein; Mathias Gautel; Julio M Fernandez
Journal: J Struct Biol Date: 2002 Jan-Feb Impact factor: 2.867

Review 3. Role of titin in vertebrate striated muscle.

Authors: L Tskhovrebova; J Trinick
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2002-02-28 Impact factor: 6.237

4. Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments.

Authors: K Trombitás; M Greaser; S Labeit; J P Jin; M Kellermayer; M Helmes; H Granzier
Journal: J Cell Biol Date: 1998-02-23 Impact factor: 10.539

5. Elasticity and unfolding of single molecules of the giant muscle protein titin.

Authors: L Tskhovrebova; J Trinick; J A Sleep; R M Simmons
Journal: Nature Date: 1997-05-15 Impact factor: 49.962

6. Characterizing titin's I-band Ig domain region as an entropic spring.

Authors: W A Linke; M R Stockmeier; M Ivemeyer; H Hosser; P Mundel
Journal: J Cell Sci Date: 1998-06 Impact factor: 5.285

7. A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates.

Authors: C C Witt; N Olivieri; T Centner; B Kolmerer; S Millevoi; J Morell; D Labeit; S Labeit; H Jockusch; A Pastore
Journal: J Struct Biol Date: 1998 Impact factor: 2.867

8. Mechanics and structure of titin oligomers explored with atomic force microscopy.

Authors: Miklós S Z Kellermayer; Carlos Bustamante; Henk L Granzier
Journal: Biochim Biophys Acta Date: 2003-06-05

9. Molecular basis of passive stress relaxation in human soleus fibers: assessment of the role of immunoglobulin-like domain unfolding.

Authors: K Trombitás; Y Wu; M McNabb; M Greaser; M S Z Kellermayer; S Labeit; H Granzier
Journal: Biophys J Date: 2003-11 Impact factor: 4.033