AIMS: Age is one of the most powerful determinants of prognosis in myocardial infarction, but there is comparatively little recent data across the whole spectrum of acute coronary syndromes (ACS). We examined the impact of increasing age on clinical presentation and hospital outcome in a large sample of patients with ACS. METHODS AND RESULTS: Patients (n = 10 253) from the Euroheart ACS survey in 103 hospitals in 25 countries were investigated. There was a significant inverse association between the age and the likelihood of presenting with ST-elevation. For each decade of life, the odds of presenting with ST-elevation decreased by 0.82 [95% confidence interval (CI) 0.79-0.84]; P < 0.0001. Elderly patients were considerably less often treated by cardiologists, less extensively investigated, and, when presenting with ST-elevation ACS, less likely to be treated with reperfusion. Compared with patients <55 years, the odds ratios of hospital mortality were 1.87 (1.21-2.88) at age 55-64, 3.70 (2.51-5.44) at age 65-74, 6.23 (4.25-9.14) at age 75-84, and 14.5 (9.47-22.1) among patients > or =85 years, with no major differences across different types of admission or discharge diagnoses. CONCLUSION: Elderly ACS patients were less likely to present with ST-elevation but had substantial in-hospital mortality, yet they were markedly less intensively treated and investigated.
AIMS: Age is one of the most powerful determinants of prognosis in myocardial infarction, but there is comparatively little recent data across the whole spectrum of acute coronary syndromes (ACS). We examined the impact of increasing age on clinical presentation and hospital outcome in a large sample of patients with ACS. METHODS AND RESULTS:Patients (n = 10 253) from the Euroheart ACS survey in 103 hospitals in 25 countries were investigated. There was a significant inverse association between the age and the likelihood of presenting with ST-elevation. For each decade of life, the odds of presenting with ST-elevation decreased by 0.82 [95% confidence interval (CI) 0.79-0.84]; P < 0.0001. Elderly patients were considerably less often treated by cardiologists, less extensively investigated, and, when presenting with ST-elevation ACS, less likely to be treated with reperfusion. Compared with patients <55 years, the odds ratios of hospital mortality were 1.87 (1.21-2.88) at age 55-64, 3.70 (2.51-5.44) at age 65-74, 6.23 (4.25-9.14) at age 75-84, and 14.5 (9.47-22.1) among patients > or =85 years, with no major differences across different types of admission or discharge diagnoses. CONCLUSION: Elderly ACS patients were less likely to present with ST-elevation but had substantial in-hospital mortality, yet they were markedly less intensively treated and investigated.
Authors: Khalid A Alnemer; Hussam F Alfaleh; Khalid F Alhabib; Anhar Ullah; Ahmad Hersi; Shukri Alsaif; Amir Taraben; Gamal Hussein; Modather Butt Journal: J Saudi Heart Assoc Date: 2012-08-27
Authors: Joon Seok Choi; Min Jee Kim; Yong Un Kang; Chang Seong Kim; Eun Hui Bae; Seong Kwon Ma; Young-Keun Ahn; Myung Ho Jeong; Young Jo Kim; Myeong Chan Cho; Chong Jin Kim; Soo Wan Kim Journal: Clin J Am Soc Nephrol Date: 2013-02-21 Impact factor: 8.237
Authors: Milosz Jaguszewski; Jelena-R Ghadri; Johanna Diekmann; Roxana D Bataiosu; Jens P Hellermann; Annahita Sarcon; Asim Siddique; Lukas Baumann; Barbara E Stähli; Thomas F Lüscher; Willibald Maier; Christian Templin Journal: Clin Res Cardiol Date: 2014-08-21 Impact factor: 5.460