Literature DB >> 16464623

The promise of protein C.

John H Griffin1, José A Fernández, Laurent O Mosnier, Dong Liu, Tong Cheng, Huang Guo, Berislav V Zlokovic.   

Abstract

Protein C, a vitamin K-dependent serine protease zymogen that circulates in plasma, is converted by limited proteolysis to activated protein C (APC) by the thrombin-thrombomodulin complex. APC exerts anticoagulant, antiinflammatory, cytoprotective, and antiapoptotic activities. Recombinant APC therapy reduces mortality in severe sepsis patients. This review summarizes data from clinical observations, from in vitro studies, and from animal models of focal ischemic injury that provide a compelling rationale for clinical trials of APC for ischemic stroke.

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Year:  2006        PMID： 16464623     DOI： 10.1016/j.bcmd.2005.12.023

Source DB:  PubMed          Journal:  Blood Cells Mol Dis        ISSN： 1079-9796            Impact factor:   3.039


  18 in total

Review 1.  Cytoprotective protein C pathways and implications for stroke and neurological disorders.

Authors:  Berislav V Zlokovic; John H Griffin
Journal:  Trends Neurosci       Date:  2011-02-25       Impact factor: 13.837

2.  Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.

Authors:  Meilang Xue; Suat Dervish; Leonard C Harrison; Gregory Fulcher; Christopher J Jackson
Journal:  J Biol Chem       Date:  2012-03-23       Impact factor: 5.157

3.  Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatory period.

Authors:  Yuan Cheng; Kazuhiro Kawamura; Masashi Deguchi; Seido Takae; Sabine M Mulders; Aaron J W Hsueh
Journal:  Mol Endocrinol       Date:  2011-12-29

4.  Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function.

Authors:  Nikita Minhas; Meilang Xue; Christopher J Jackson
Journal:  Cell Mol Life Sci       Date:  2016-12-22       Impact factor: 9.261

Review 5.  Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C.

Authors:  Arun Paul Amar; Abhay P Sagare; Zhen Zhao; Yaoming Wang; Amy R Nelson; John H Griffin; Berislav V Zlokovic
Journal:  Neuropharmacology       Date:  2017-09-18       Impact factor: 5.250

6.  Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.

Authors:  Yaoming Wang; Ranjeet Kumar Sinha; Laurent O Mosnier; John H Griffin; Berislav V Zlokovic
Journal:  Blood Cells Mol Dis       Date:  2013-03-29       Impact factor: 3.039

7.  Endogenous protein C is essential for the functional integrity of human endothelial cells.

Authors:  Meilang Xue; Nikita Minhas; Shu-Oi Chow; Suat Dervish; Philip N Sambrook; Lyn March; Christopher J Jackson
Journal:  Cell Mol Life Sci       Date:  2010-02-03       Impact factor: 9.261

8.  Transcriptional characteristics of different sized follicles in relation to embryo transferability: potential role of hepatocyte growth factor signalling.

Authors:  A L Nivet; M C Léveillé; A Leader; M A Sirard
Journal:  Mol Hum Reprod       Date:  2016-04-28       Impact factor: 4.025

9.  Blood coagulation and fibrinolysis in male patients with hypogonadotropic hypogonadism: plasma factor V and factor X activities increase in hypogonadotropic hypogonadism.

Authors:  C Erem; M Kocak; A Hacihasanoglu; M Yilmaz
Journal:  J Endocrinol Invest       Date:  2008-06       Impact factor: 4.256

10.  Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.

Authors:  M Anna Kowalska; Shawn A Mahmud; Michele P Lambert; Mortimer Poncz; Arne Slungaard
Journal:  Blood       Date:  2007-05-31       Impact factor: 22.113
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