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Literature DB >> 16464592

Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

Sébastien Tilloy¹, Véronique Monnaert, Laurence Fenart, Hervé Bricout, Roméo Cecchelli, Eric Monflier.

Abstract

Co-incubations of various beta-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood-brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-beta-cyclodextrin and Crysme-beta-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.

Entities: Chemical Gene

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Year: 2006 PMID： 16464592 DOI： 10.1016/j.bmcl.2006.01.049

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

8 in total

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4. Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs.

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Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

1. Protective effect of memantine against Doxorubicin toxicity in primary neuronal cell cultures: influence a development stage.

2. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats.

3. Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies.

4. Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs.

5. Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles.

6. Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer's Disease.

7. Neurotoxicity of cancer chemotherapy.

8. Focused shockwave induced blood-brain barrier opening and transfection.