| Literature DB >> 16464588 |
Hengmiao Cheng1, Kristin M Lundy DeMello, Jin Li, Subas M Sakya, Kazuo Ando, K Kawamura, Tomoki Kato, Robert J Rafka, Burton H Jaynes, Carl B Ziegler, Rod Stevens, Lisa A Lund, Donald W Mann, Carolyn Kilroy, Michelle L Haven, Erik L Nimz, Jason K Dutra, Chao Li, Martha L Minich, Nicole L Kolosko, Carol Petras, Annette M Silvia, Scott B Seibel.
Abstract
The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure-activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrated a canine whole blood COX-2 inhibitory IC50 of 12 nM and selectivity ratio of COX-1/COX-2 greater than 4000-fold.Entities:
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Year: 2006 PMID： 16464588 DOI： 10.1016/j.bmcl.2006.01.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823