Literature DB >> 16464578

Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.

Tao Jiang1, Kelli L Kuhen, Karen Wolff, Hong Yin, Kimberly Bieza, Jeremy Caldwell, Badry Bursulaya, Tove Tuntland, Kanyin Zhang, Donald Karanewsky, Yun He.   

Abstract

A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.

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Year:  2006        PMID： 16464578     DOI： 10.1016/j.bmcl.2006.01.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes.

Authors:  Kevin X Rodriguez; Erin N Howe; Emily P Bacher; Miranda Burnette; Jennifer L Meloche; Jayda Meisel; Patricia Schnepp; Xuejuan Tan; Mayland Chang; Jeremiah Zartman; Siyuan Zhang; Brandon L Ashfeld
Journal:  ChemMedChem       Date:  2019-07-01       Impact factor: 3.466

Review 2.  1,3-Dipolar cycloaddition reactions of isatin-derived azomethine ylides for the synthesis of spirooxindole and indole-derived scaffolds: recent developments.

Authors:  Fatemeh Rostami Miankooshki; Mohammad Bayat; Shima Nasri; Narges Habibi Samet
Journal:  Mol Divers       Date:  2022-08-04       Impact factor: 3.364

Review 3.  Therapeutic Potential of Spirooxindoles as Antiviral Agents.

Authors:  Na Ye; Haiying Chen; Eric A Wold; Pei-Yong Shi; Jia Zhou
Journal:  ACS Infect Dis       Date:  2016-05-05       Impact factor: 5.084

Review 4.  Molecular diversity of spirooxindoles. Synthesis and biological activity.

Authors:  Tetyana L Pavlovska; Ruslan Gr Redkin; Victoria V Lipson; Dmytro V Atamanuk
Journal:  Mol Divers       Date:  2015-09-29       Impact factor: 2.943

5.  Effect of Structure on Charge Distribution in the Isatin Anions in Aprotic Environment: Spectral Study.

Authors:  Pavol Tisovský; Róbert Šandrik; Miroslav Horváth; Jana Donovalová; Juraj Filo; Martin Gáplovský; Klaudia Jakusová; Marek Cigáň; Róbert Sokolík; Anton Gáplovský
Journal:  Molecules       Date:  2017-11-14       Impact factor: 4.411

6.  Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.

Authors:  Nadeem Siddiqui; M Shamsher Alam; James P Stables
Journal:  Eur J Med Chem       Date:  2011-03-10       Impact factor: 6.514

7.  1H-1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation.

Authors:  Kewal Kumar; Bruno Pradines; Marilyn Madamet; Rémy Amalvict; Nicolas Benoit; Vipan Kumar
Journal:  Eur J Med Chem       Date:  2014-10-13       Impact factor: 6.514

8.  Heterogeneous photocatalytic cyanomethylarylation of alkenes with acetonitrile: synthesis of diverse nitrogenous heterocyclic compounds.

Authors:  Guanglong Pan; Qian Yang; Wentao Wang; Yurong Tang; Yunfei Cai
Journal:  Beilstein J Org Chem       Date:  2021-05-17       Impact factor: 2.883

9.  Three-component synthesis of new unsymmetrical oxindoles via Friedel-Crafts type reaction.

Authors:  Somayeh Ahadi; Leila Moafi; Afsaneh Feiz; Ayoob Bazgir
Journal:  Tetrahedron       Date:  2011-03-09       Impact factor: 2.457

10.  An efficient synthesis of 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones catalyzed by sulfonated β-CD as a supramolecular catalyst in water.

Authors:  Yogesh A Tayade; Dipak R Patil; Yogesh B Wagh; Asha D Jangle; Dipak S Dalal
Journal:  Tetrahedron Lett       Date:  2014-12-12       Impact factor: 2.415
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