| Literature DB >> 16464577 |
Larisa Oresmaa1, Hanna Kotikoski, Matti Haukka, Olli Oksala, Esko Pohjala, Heikki Vapaatalo, Pirjo Vainiotalo, Paula Aulaskari.
Abstract
Esters of 1-(H)-imidazole-5-nitrolic acid and 1-methyl-imidazole-5-carboxamide oxime were prepared to study the effect of esterification on the ocular effects of these compounds. Esterifications were performed with acid chloride. Acid chloride also reacts with the ring nitrogen of 1-(H)-imidazole-5-nitrolic acid, but the desired esters could be selectively prepared by adjustment of the reaction conditions. Esterification led to loss of the ocular effects exhibited by the parent compounds.Entities:
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Year: 2006 PMID： 16464577 DOI： 10.1016/j.bmcl.2006.01.068
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823