Literature DB >> 16463857

Three-year outcome of shunted idiopathic NPH patients.

G Aygok1, A Marmarou, H F Young.   

Abstract

The incidence of idiopathic normal pressure hydrocephalus (iNPH) has increased as a result of improved longevity. This report describes the 3-year outcome of shunted iNPH patients compared to three-month outcome after shunting. Patients (n = 50) (Age 70.4 +/- 8.9) admitted to our service were diagnosed and treated according to a fixed protocol for management of iNPH and after shunting were followed at least three times per year in clinic. The outcome of 50 patients was graded according to the level of improvement in symptoms as Excellent/Good, Partial or None in each category of Gait, Incontinence and Dementia. If we lump favorable (excellent, good, partial recovery) vs poor recovery (none), we found from 3 months to 3 years, a moderate decline in gait performance (91% to 75%), a retention of memory improvement (80%-80%) and an improvement in incontinence occurred over time (70%-82.5%). With proper diagnosis and management of iNPH, shunting of patients is associated with a favorable risk/benefit ratio that is reasonably long lasting.

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Year:  2005        PMID: 16463857     DOI: 10.1007/3-211-32318-x_49

Source DB:  PubMed          Journal:  Acta Neurochir Suppl        ISSN: 0065-1419


  5 in total

1.  Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology.

Authors:  Roy Hamilton; Sunil Patel; Edward B Lee; Eric M Jackson; Joanna Lopinto; Steven E Arnold; Christopher M Clark; Anuj Basil; Leslie M Shaw; Sharon X Xie; M Sean Grady; John Q Trojanowski
Journal:  Ann Neurol       Date:  2010-10       Impact factor: 10.422

2.  Normal pressure hydrocephalus: how often does the diagnosis hold water?

Authors:  Bryan T Klassen; J Eric Ahlskog
Journal:  Neurology       Date:  2011-08-17       Impact factor: 9.910

3.  Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation.

Authors:  Yafell Serulle; Henry Rusinek; Ivan I Kirov; Hannah Milch; Els Fieremans; Alexander B Baxter; John McMenamy; Rajan Jain; Jeffrey Wisoff; James Golomb; Oded Gonen; Ajax E George
Journal:  J Neurol       Date:  2014-08-01       Impact factor: 4.849

4.  Long-term effects of complications and vascular comorbidity in idiopathic normal pressure hydrocephalus: a quality registry study.

Authors:  Kerstin Andrén; Carsten Wikkelsö; Nina Sundström; Simon Agerskov; Hanna Israelsson; Katarina Laurell; Per Hellström; Mats Tullberg
Journal:  J Neurol       Date:  2017-11-29       Impact factor: 4.849

5.  Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus.

Authors:  Chihiro Akiba; Madoka Nakajima; Masakazu Miyajima; Ikuko Ogino; Yumiko Motoi; Kaito Kawamura; Satoshi Adachi; Akihide Kondo; Hidenori Sugano; Takahiko Tokuda; Kazuhiro Irie; Hajime Arai
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

  5 in total

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