| Literature DB >> 16462800 |
Hafid Ait-Oufella1, Benoît L Salomon, Stéphane Potteaux, Anna-Karin L Robertson, Pierre Gourdy, Joffrey Zoll, Régine Merval, Bruno Esposito, José L Cohen, Sylvain Fisson, Richard A Flavell, Göran K Hansson, David Klatzmann, Alain Tedgui, Ziad Mallat.
Abstract
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.Entities:
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Year: 2006 PMID： 16462800 DOI： 10.1038/nm1343
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440