Literature DB >> 16462081

Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi.

Quan-Bin Han1, Yu-Lin Wang, Ling Yang, Ting-Fai Tso, Chun-Feng Qiao, Jing-Zheng Song, Li-Jia Xu, Shi-Lin Chen, Da-Jian Yang, Hong-Xi Xu.   

Abstract

Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

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Year:  2006        PMID： 16462081     DOI： 10.1248/cpb.54.265

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  15 in total

1.  Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines.

Authors:  Chariya Hahnvajanawong; Wongwarut Boonyanugomol; Tapanawan Nasomyon; Watcharin Loilome; Nisana Namwat; Natthinee Anantachoke; Wichittra Tassaneeyakul; Banchob Sripa; Wises Namwat; Vichai Reutrakul
Journal:  World J Gastroenterol       Date:  2010-05-14       Impact factor: 5.742

Review 2.  Chemistry and biology of the caged Garcinia xanthones.

Authors:  Oraphin Chantarasriwong; Ayse Batova; Warinthorn Chavasiri; Emmanuel A Theodorakis
Journal:  Chemistry       Date:  2010-09-03       Impact factor: 5.236

3.  Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.

Authors:  Yulin Ren; Susan Matthew; Daniel D Lantvit; Tran Ngoc Ninh; Heebyung Chai; James R Fuchs; Djaja D Soejarto; Esperanza J Carcache de Blanco; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2011-03-23       Impact factor: 4.050

4.  Proteasome-inhibitory and cytotoxic constituents of Garcinia lateriflora: absolute configuration of caged xanthones.

Authors:  Yulin Ren; Daniel D Lantvit; Esperanza J Carcache de Blanco; Leonardus B S Kardono; Soedarsono Riswan; Heebyung Chai; Charles E Cottrell; Norman R Farnsworth; Steven M Swanson; Yuanqing Ding; Xing-Cong Li; Jannie P J Marais; Daneel Ferreira; A Douglas Kinghorn
Journal:  Tetrahedron       Date:  2010-07-17       Impact factor: 2.457

5.  Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo.

Authors:  Parichart Boueroy; Chariya Hahnvajanawong; Thidarut Boonmars; Sunitta Saensa-Ard; Natthinee Anantachoke; Kulthida Vaeteewoottacharn; Vichai Reutrakul
Journal:  Oncol Lett       Date:  2016-10-18       Impact factor: 2.967

6.  Absolute configuration of (-)-gambogic acid, an antitumor agent.

Authors:  Yulin Ren; Chunhua Yuan; Hee-byung Chai; Yuanqing Ding; Xing-Cong Li; Daneel Ferreira; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2010-11-10       Impact factor: 4.050

Review 7.  Recent research on bioactive xanthones from natural medicine: Garcinia hanburyi.

Authors:  Buyun Jia; Shanshan Li; Xuerui Hu; Guangyu Zhu; Weidong Chen
Journal:  AAPS PharmSciTech       Date:  2015-07-08       Impact factor: 3.246

8.  Natural compounds with P2X7 receptor-modulating properties.

Authors:  Wolfgang Fischer; Nicole Urban; Kerstin Immig; Heike Franke; Michael Schaefer
Journal:  Purinergic Signal       Date:  2013-10-27       Impact factor: 3.765

9.  Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STAT/JAK Signaling Pathway.

Authors:  Linfeng Xu; Yuanzhi Lao; Yanhui Zhao; Jian Qin; Wenwei Fu; Yingjia Zhang; Hongxi Xu
Journal:  Biomed Res Int       Date:  2015-05-18       Impact factor: 3.411

10.  The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation.

Authors:  Xin Li; Yuanzhi Lao; Hong Zhang; Xiaoyu Wang; Hongsheng Tan; Zhixiu Lin; Hongxi Xu
Journal:  BMC Cancer       Date:  2015-04-11       Impact factor: 4.430
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