Literature DB >> 16462054

5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.

Jie Liu1, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo.   

Abstract

5alpha-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5alpha-lanosta-7,9(11),24-triene-15alpha,26-dihydroxy-3-one with an IC(50) of 10.6 microM and 41.9 microM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.

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Year:  2006        PMID： 16462054     DOI： 10.1248/bpb.29.392

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  6 in total

1.  Isolation and HPLC Quantitative Determination of 5α-Reductase Inhibitors from Tectona grandis L.f. Leaf Extract.

Authors:  Kamonlak Insumrong; Kornkanok Ingkaninan; Neti Waranuch; Nutchaninad Tanuphol; Wudtichai Wisuitiprot; Trinop Promgool; Nungruthai Suphrom
Journal:  Molecules       Date:  2022-04-30       Impact factor: 4.927

2.  Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats.

Authors:  Fang Wang; Zhongkai Zhou; Xiaochong Ren; Yuyang Wang; Rui Yang; Jinhua Luo; Padraig Strappe
Journal:  Lipids Health Dis       Date:  2015-05-22       Impact factor: 3.876

Review 3.  Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review.

Authors:  Darija Cör; Željko Knez; Maša Knez Hrnčič
Journal:  Molecules       Date:  2018-03-13       Impact factor: 4.411

4.  The Possible Role of PD-1 Protein in Ganoderma lucidum-Mediated Immunomodulation and Cancer Treatment.

Authors:  Gan Wang; Le Wang; Jianlong Zhou; Xiaoxin Xu
Journal:  Integr Cancer Ther       Date:  2019 Jan-Dec       Impact factor: 3.279

Review 5.  Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents.

Authors:  Codruţa Şoica; Mirela Voicu; Roxana Ghiulai; Cristina Dehelean; Roxana Racoviceanu; Cristina Trandafirescu; Oana-Janina Roșca; Gabriela Nistor; Marius Mioc; Alexandra Mioc
Journal:  Front Endocrinol (Lausanne)       Date:  2021-01-21       Impact factor: 5.555

6.  Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.

Authors:  Jie Liu; Kuniyoshi Shimizu; Akinobu Tanaka; Wakako Shinobu; Koichiro Ohnuki; Takanori Nakamura; Ryuichiro Kondo
Journal:  Sci Rep       Date:  2012-11-30       Impact factor: 4.379
  6 in total

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