OBJECTIVE: Pediatric sleep-disordered breathing (SDB) has a disproportionately high prevalence in children who were preterm infants (preterm children) and is associated with behavioral comorbidity. Exposure to intermittent hypoxemia and sleep disruption may contribute to cognitive impairment. We quantified the association of SDB with cognition and achievement and determined whether preterm children are at a differentially increased risk for SDB-related impairments. DESIGN: Cross-sectional analyses. SETTING: Urban community. PARTICIPANTS: Eight hundred thirty-five children, aged 8 to 11 years.Intervention(s) None. MAIN OUTCOME MEASURES: Scores on the Peabody Picture Vocabulary Test-Revised, Kaufman Assessment Battery for Children, and Continuous Performance Test. RESULTS: One hundred sixty-four children had SDB. In unadjusted analyses, children with SDB had poorer scores on almost all tests of cognition and achievement. Group differences were attenuated after adjusting for socioeconomic status; in these analyses, children with SDB scored lower on the Peabody Picture Vocabulary Test-Revised (mean +/- SE score, 100.5 +/- 1.4 vs 103.6 +/- 0.7; P = .04), and the Kaufman Assessment Battery for Children riddles and triangles subscales. Associations were stronger in preterm than in full-term children. Of the sleep measures, snoring history was most strongly correlated with indices of cognition and achievement. CONCLUSIONS: Although moderate group differences were observed for almost all cognitive measures, an attenuation of effects was observed once socioeconomic status was considered. The deficits in selective measures of academic abilities, language comprehension, and planning and organizational skills suggest a negative impact of SDB on achievement and cognition. Stronger associations in preterm children suggest the importance of screening for snoring, a good predictor of cognitive function in this population.
OBJECTIVE: Pediatric sleep-disordered breathing (SDB) has a disproportionately high prevalence in children who were preterm infants (preterm children) and is associated with behavioral comorbidity. Exposure to intermittent hypoxemia and sleep disruption may contribute to cognitive impairment. We quantified the association of SDB with cognition and achievement and determined whether preterm children are at a differentially increased risk for SDB-related impairments. DESIGN: Cross-sectional analyses. SETTING: Urban community. PARTICIPANTS: Eight hundred thirty-five children, aged 8 to 11 years.Intervention(s) None. MAIN OUTCOME MEASURES: Scores on the Peabody Picture Vocabulary Test-Revised, Kaufman Assessment Battery for Children, and Continuous Performance Test. RESULTS: One hundred sixty-four children had SDB. In unadjusted analyses, children with SDB had poorer scores on almost all tests of cognition and achievement. Group differences were attenuated after adjusting for socioeconomic status; in these analyses, children with SDB scored lower on the Peabody Picture Vocabulary Test-Revised (mean +/- SE score, 100.5 +/- 1.4 vs 103.6 +/- 0.7; P = .04), and the Kaufman Assessment Battery for Children riddles and triangles subscales. Associations were stronger in preterm than in full-term children. Of the sleep measures, snoring history was most strongly correlated with indices of cognition and achievement. CONCLUSIONS: Although moderate group differences were observed for almost all cognitive measures, an attenuation of effects was observed once socioeconomic status was considered. The deficits in selective measures of academic abilities, language comprehension, and planning and organizational skills suggest a negative impact of SDB on achievement and cognition. Stronger associations in preterm children suggest the importance of screening for snoring, a good predictor of cognitive function in this population.
Authors: Christopher M Cielo; Lourdes M DelRosso; Ignacio E Tapia; Sarah N Biggs; Gillian M Nixon; Lisa J Meltzer; Joel Traylor; Ji Young Kim; Carole L Marcus Journal: Sleep Med Date: 2016-03-15 Impact factor: 3.492
Authors: Angela R Jackman; Sarah N Biggs; Lisa M Walter; Upeka S Embuldeniya; Margot J Davey; Gillian M Nixon; Vicki Anderson; John Trinder; Rosemary S C Horne Journal: Sleep Date: 2013-11-01 Impact factor: 5.849
Authors: Carol L Rosen; Michael R Debaun; Robert C Strunk; Susan Redline; Sinziana Seicean; Daniel I Craven; Johanna C D Gavlak; Olu Wilkey; Baba Inusa; Irene Roberts; R Lucas Goodpaster; Beth Malow; Mark Rodeghier; Fenella J Kirkham Journal: Pediatrics Date: 2014-07-14 Impact factor: 7.124
Authors: Ronald D Chervin; Susan S Ellenberg; Xiaoling Hou; Carole L Marcus; Susan L Garetz; Eliot S Katz; Elise K Hodges; Ron B Mitchell; Dwight T Jones; Raanan Arens; Raouf Amin; Susan Redline; Carol L Rosen Journal: Chest Date: 2015-11 Impact factor: 9.410
Authors: Ronald D Chervin; Susan L Garetz; Deborah L Ruzicka; Elise K Hodges; Bruno J Giordani; James E Dillon; Barbara T Felt; Timothy F Hoban; Kenneth E Guire; Louise M O'Brien; Joseph W Burns Journal: J Clin Sleep Med Date: 2014-08-15 Impact factor: 4.062
Authors: H Gerry Taylor; Susan R Bowen; Dean W Beebe; Elise Hodges; Raouf Amin; Raanan Arens; Ronald D Chervin; Susan L Garetz; Eliot S Katz; Reneé H Moore; Knashawn H Morales; Hiren Muzumdar; Shalini Paruthi; Carol L Rosen; Anjali Sadhwani; Nina Hattiangadi Thomas; Janice Ware; Carole L Marcus; Susan S Ellenberg; Susan Redline; Bruno Giordani Journal: Pediatrics Date: 2016-08 Impact factor: 7.124