| Literature DB >> 16461271 |
Bernd Giebel1, Andreas Wodarz.
Abstract
Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.Entities:
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Year: 2006 PMID： 16461271 DOI： 10.1016/j.cub.2006.01.022
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834