Literature DB >> 1646123

Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels.

M Taki1, H Nakayama, Y Kanaoka.   

Abstract

A new 1,4-dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]azidopine. [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity to [3H]azidopine, but [3H]diazipine labels the channel two times more efficiently and no release of the incorported amount is observed after dithiothreitol treatment.

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Year:  1991        PMID： 1646123     DOI： 10.1016/0014-5793(91)80602-y

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

Authors:  J Striessnig; B J Murphy; W A Catterall
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

2.  Identification of 1,4-dihydropyridine binding regions within the alpha 1 subunit of skeletal muscle Ca2+ channels by photoaffinity labeling with diazipine.

Authors:  H Nakayama; M Taki; J Striessnig; H Glossmann; W A Catterall; Y Kanaoka
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

3.  Synthesis of nitrodiazirinyl derivatives of neurotoxin II from Naja naja oxiana and their interaction with the Torpedo californica nicotinic acetylcholine receptor.

Authors:  Y N Utkin; Y Hatanaka; P Franke; J Machold; F Hucho; V I Tsetlin
Journal:  J Protein Chem       Date:  1995-05
  3 in total

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