| Literature DB >> 16460940 |
Lee A McDermott1, Brian Higgins, Mary Simcox, Kin-Chun Luk, Tom Nevins, Kenneth Kolinsky, Melissa Smith, Hong Yang, Jia K Li, Yingsi Chen, June Ke, Navita Mallalieu, Tom Egan, Stan Kolis, Aruna Railkar, Louise Gerber, Jin-Jun Liu, Fred Konzelmann, Zhuming Zhang, Tom Flynn, Omar Morales, Yi Chen.
Abstract
RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg.Entities:
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Year: 2006 PMID： 16460940 DOI： 10.1016/j.bmcl.2005.12.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823