| Literature DB >> 16460937 |
Terrence L Smalley1, Andrew J Peat, Joyce A Boucheron, Scott Dickerson, Dulce Garrido, Frank Preugschat, Stephanie L Schweiker, Stephen A Thomson, Tony Y Wang.
Abstract
A set of novel heterocyclic pyrimidyl hydrazones has been synthesized as inhibitors of glycogen synthase kinase-3 (GSK-3) with the most active exhibiting low nanomolar activity. Quantum mechanical calculations indicate that of the conformational factors that could determine binding affinity, the planarity of the phenyl ring in relation to the central core and the conformation of the hydrazone chain may be the most influential.Entities:
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Year: 2006 PMID： 16460937 DOI： 10.1016/j.bmcl.2006.01.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823