| Literature DB >> 16460932 |
Roopa Rai1, Aleksandr Kolesnikov, Paul A Sprengeler, Steven Torkelson, Tony Ton, Bradley A Katz, Christine Yu, John Hendrix, William D Shrader, Robin Stephens, Ronnell Cabuslay, Ellen Sanford, Wendy B Young.
Abstract
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.Entities:
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Year: 2006 PMID： 16460932 DOI： 10.1016/j.bmcl.2006.01.017
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823