| Literature DB >> 16460841 |
Elizabeth Head1, Edward G Barrett, M Paul Murphy, Pritam Das, Mihaela Nistor, Floyd Sarsoza, Charles C Glabe, Rakez Kayed, Saskia Milton, Vitaly Vasilevko, Norton W Milgram, Michael G Agadjanyan, David H Cribbs, Carl W Cotman.
Abstract
We describe a study testing fibrillar beta-amyloid(1-42) (Abeta42) vaccination in dogs. Three young beagles (4.6 years) were immunized twice with Abeta42 and a Th1 adjuvant (TiterMax Gold). Animals generated primarily IgG2 and IgM antibody responses, which were specific for the Abeta(11-30) region of Abeta(1-42). Next, 3 aged beagles (8.9-13.8 years) were immunized 4 times with Abeta(42) and a Th2 adjuvant (Alum). We observed an acute increase in IgG2, a slower increase in IgG1 and Abeta antibodies of broader specificity (Abeta(1-15>) Abeta(11-30>) Abeta(6-20)). A nonsignificant increase in CSF Abeta(1-40) and decrease in Abeta(1-40/1-42) in cortex was detected. Canines may be a useful system for testing an Abeta vaccine.Entities:
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Year: 2006 PMID： 16460841 DOI： 10.1016/j.vaccine.2005.12.058
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641