AIM: To evaluate anti-Müllerian hormone (AMH) levels in patients with clinical and molecular diagnosis of 5alpha-reductase 2 deficiency. PATIENTS AND METHODS: Data from 14 patients whose age ranged from 21 days to 29 years were analyzed according to age and pubertal stage. Sexual ambiguity was rated as Prader III in 11 patients. LH, FSH, testosterone (T), dihydrotestosterone (DHT) and AMH serum levels were measured in all but two patients, who had been previously submitted to gonadectomy; T and DHT were also measured in 20 age-matched controls. RESULTS: Gonadotropin levels were normal in all but one patient who retained gonads (six of whom had reached puberty) and T/DHT ratio was elevated in all patients when compared to controls. All prepubertal patients had AMH levels < -1 SD for age, while most pubertal patients had AMH levels compatible with pubertal stage. CONCLUSIONS: Prepubertal patients with 5alpha-reductase 2 deficiency have AMH values in the lower part of the normal range. These data indicate that T does not need to be converted to DHT to inhibit AMH secretion by Sertoli cells.
AIM: To evaluate anti-Müllerian hormone (AMH) levels in patients with clinical and molecular diagnosis of 5alpha-reductase 2 deficiency. PATIENTS AND METHODS: Data from 14 patients whose age ranged from 21 days to 29 years were analyzed according to age and pubertal stage. Sexual ambiguity was rated as Prader III in 11 patients. LH, FSH, testosterone (T), dihydrotestosterone (DHT) and AMH serum levels were measured in all but two patients, who had been previously submitted to gonadectomy; T and DHT were also measured in 20 age-matched controls. RESULTS: Gonadotropin levels were normal in all but one patient who retained gonads (six of whom had reached puberty) and T/DHT ratio was elevated in all patients when compared to controls. All prepubertal patients had AMH levels < -1 SD for age, while most pubertal patients had AMH levels compatible with pubertal stage. CONCLUSIONS: Prepubertal patients with 5alpha-reductase 2 deficiency have AMH values in the lower part of the normal range. These data indicate that T does not need to be converted to DHT to inhibit AMH secretion by Sertoli cells.
Authors: Georgette Beatriz De Paula; Beatriz Amstalden Barros; Stela Carpini; Bruna Jordan Tincani; Tais Nitsch Mazzola; Mara Sanches Guaragna; Cristiane Santos da Cruz Piveta; Laurione Candido de Oliveira; Juliana Gabriel Ribeiro Andrade; Guilherme Guaragna-Filho; Pedro Perez Barbieri; Nathalia Montibeler Ferreira; Marcio Lopes Miranda; Ezequiel Moreira Gonçalves; Andre Moreno Morcillo; Nilma Lucia Viguetti-Campos; Sofia Helena Valente Lemos-Marini; Roberto Benedito de Paiva Silva; Antonia Paula Marques-de-Faria; Maricilda Palandi De Mello; Andrea Trevas Maciel-Guerra; Gil Guerra-Junior Journal: Int J Endocrinol Date: 2016-11-28 Impact factor: 3.257
Authors: Letícia Ribeiro Oliveira; Carlos Alberto Longui; Guilherme Guaragna-Filho; José Luiz Costa; Rafael Lanaro; David Antônio Silva; Maria Izabel Chiamolera; Maricilda Palandi de Mello; André Moreno Morcillo; Andrea Trevas Maciel-Guerra; Gil Guerra-Junior Journal: Endocr Connect Date: 2020-11 Impact factor: 3.335