| Literature DB >> 16459315 |
Heike Biebermann1, Tamara R Castañeda, Frank van Landeghem, Andreas von Deimling, Frederike Escher, Georg Brabant, Johannes Hebebrand, Anke Hinney, Matthias H Tschöp, Annette Grüters, Heiko Krude.
Abstract
Pro-opiomelanocortin (POMC) expressing neurons mediate the regulation of orexigenic drive by peripheral hormones such as leptin, cholecystokinin, ghrelin, and insulin. Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset human obesity. In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans.Entities:
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Year: 2006 PMID： 16459315 DOI： 10.1016/j.cmet.2006.01.007
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287