Literature DB >> 16459306

Certainly can't live without this: SIRT6.

Joseph T Rodgers1, Pere Puigserver.   

Abstract

Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.

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Year:  2006        PMID： 16459306     DOI： 10.1016/j.cmet.2006.01.009

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage.

Authors:  Erika Koltai; Zhongfu Zhao; Zsombor Lacza; Attila Cselenyak; Gabriella Vacz; Csaba Nyakas; Istvan Boldogh; Noriko Ichinoseki-Sekine; Zsolt Radak
Journal:  Rejuvenation Res       Date:  2011-08-25       Impact factor: 4.663

2.  Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts.

Authors:  M Yasuda; D R Wilson; S D Fugmann; R Moaddel
Journal:  Anal Chem       Date:  2011-09-02       Impact factor: 6.986

Review 3.  The functional significance of nuclear receptor acetylation.

Authors:  Vladimir M Popov; Chenguang Wang; L Andrew Shirley; Anne Rosenberg; Shengwen Li; Marja Nevalainen; Maofu Fu; Richard G Pestell
Journal:  Steroids       Date:  2007-02-07       Impact factor: 2.668

4.  Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients.

Authors:  Jens U Marquardt; Kerstin Fischer; Katharina Baus; Anubha Kashyap; Shengyun Ma; Markus Krupp; Matthias Linke; Andreas Teufel; Ulrich Zechner; Dennis Strand; Snorri S Thorgeirsson; Peter R Galle; Susanne Strand
Journal:  Hepatology       Date:  2013-07-30       Impact factor: 17.425

5.  Synthesis and characterization of a SIRT6 open tubular column: predicting deacetylation activity using frontal chromatography.

Authors:  Nagendra Singh; Sarangan Ravichandran; Darrell D Norton; Sebastian D Fugmann; Ruin Moaddel
Journal:  Anal Biochem       Date:  2013-01-29       Impact factor: 3.365

6.  N-Acylethanolamines Bind to SIRT6.

Authors:  Minna Rahnasto-Rilla; Tarja Kokkola; Elina Jarho; Maija Lahtela-Kakkonen; Ruin Moaddel
Journal:  Chembiochem       Date:  2015-11-26       Impact factor: 3.164

7.  The Identification of a SIRT6 Activator from Brown Algae Fucus distichus.

Authors:  Minna K Rahnasto-Rilla; Padraig McLoughlin; Tomasz Kulikowicz; Maire Doyle; Vilhelm A Bohr; Maija Lahtela-Kakkonen; Luigi Ferrucci; Maria Hayes; Ruin Moaddel
Journal:  Mar Drugs       Date:  2017-06-21       Impact factor: 5.118

8.  Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative Disease.

Authors:  Swapnil Raj; Liston Augustine Dsouza; Shailendra Pratap Singh; Abhinav Kanwal
Journal:  Front Pharmacol       Date:  2020-12-07       Impact factor: 5.810

9.  SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages.

Authors:  Ying Zou; Jiaqi Zhang; Jiawei Xu; Lanya Fu; Yizhou Xu; Xianghai Wang; Zhenlin Li; Lixin Zhu; Hao Sun; Hui Zheng; Jiasong Guo
Journal:  Cell Biosci       Date:  2021-12-14       Impact factor: 7.133

10.  Pharmacophore model of the quercetin binding site of the SIRT6 protein.

Authors:  S Ravichandran; N Singh; D Donnelly; M Migliore; P Johnson; C Fishwick; B T Luke; B Martin; S Maudsley; S D Fugmann; R Moaddel
Journal:  J Mol Graph Model       Date:  2014-01-20       Impact factor: 2.518
  10 in total

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