Literature DB >> 1645909

Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein.

S Takase-Yoden1, T Kikuchi, S G Siddell, F Taguchi.   

Abstract

A recombinant baculovirus system has been used to express the amino terminal half of the murine coronavirus (JHMV) peplomer glycoprotein in insect cells. The expressed polypeptide is glycosylated and is recognized by a set of monoclonal antibodies (mAbs) specific for JHMV S protein. Three of these mAbs have a very high neutralizing activity for JHMV but not for other MHV strains. These results indicate that JHMV-specific, major neutralizing epitopes reside in the amino terminal S1 subunit of the peplomer glycoprotein.

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Year:  1991        PMID： 1645909      PMCID： PMC7133859          DOI： 10.1016/0168-1702(91)90011-j

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  24 in total

1.  RNA recombination of coronaviruses: localization of neutralizing epitopes and neuropathogenic determinants on the carboxyl terminus of peplomers.

Authors:  S Makino; J O Fleming; J G Keck; S A Stohlman; M M Lai
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

2.  The peplomer protein E2 of coronavirus JHM as a determinant of neurovirulence: definition of critical epitopes by variant analysis.

Authors:  H Wege; J Winter; R Meyermann
Journal:  J Gen Virol       Date:  1988-01       Impact factor: 3.891

3.  Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies.

Authors:  J O Fleming; M D Trousdale; F A el-Zaatari; S A Stohlman; L P Weiner
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

4.  Resistance to highly virulent mouse hepatitis virus acquired by mice after low-virulence infection: enhanced antiviral activity of macrophages.

Authors:  F Taguchi; A Yamada; K Fujiwara
Journal:  Infect Immun       Date:  1980-07       Impact factor: 3.441

5.  Hybridoma antibodies to the murine coronavirus JHM: characterization of epitopes on the peplomer protein (E2).

Authors:  H Wege; R Dörries; H Wege
Journal:  J Gen Virol       Date:  1984-11       Impact factor: 3.891

6.  Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S.

Authors:  B Delmas; D Rasschaert; M Godet; J Gelfi; H Laude
Journal:  J Gen Virol       Date:  1990-06       Impact factor: 3.891

7.  Monoclonal antibodies to the peplomer glycoprotein of coronavirus mouse hepatitis virus identify two subunits and detect a conformational change in the subunit released under mild alkaline conditions.

Authors:  D G Weismiller; L S Sturman; M J Buchmeier; J O Fleming; K V Holmes
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

8.  Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: activation of cell-fusing activity of virions by trypsin and separation of two different 90K cleavage fragments.

Authors:  L S Sturman; C S Ricard; K V Holmes
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

9.  Antigenic relationships of murine coronaviruses: analysis using monoclonal antibodies to JHM (MHV-4) virus.

Authors:  J O Fleming; S A Stohlman; R C Harmon; M M Lai; J A Frelinger; L P Weiner
Journal:  Virology       Date:  1983-12       Impact factor: 3.616

10.  Antigenic differentiation of mouse hepatitis viruses by neutralization test.

Authors:  F Taguchi; S Makino; K Fujiwara
Journal:  Microbiol Immunol       Date:  1982       Impact factor: 1.955
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  8 in total

1.  Identification of an immunodominant linear neutralization domain on the S2 portion of the murine coronavirus spike glycoprotein and evidence that it forms part of complex tridimensional structure.

Authors:  C Daniel; R Anderson; M J Buchmeier; J O Fleming; W J Spaan; H Wege; P J Talbot
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

2.  Processing and antigenicity of entire and anchor-free spike glycoprotein S of coronavirus TGEV expressed by recombinant baculovirus.

Authors:  M Godet; D Rasschaert; H Laude
Journal:  Virology       Date:  1991-12       Impact factor: 3.616

3.  A single amino acid change within antigenic domain II of the spike protein of bovine coronavirus confers resistance to virus neutralization.

Authors:  D Yoo; D Deregt
Journal:  Clin Diagn Lab Immunol       Date:  2001-03

4.  Design and Construction of Chimeric VP8-S2 Antigen for Bovine Rotavirus and Bovine Coronavirus.

Authors:  Khadijeh Nasiri; Mohammadreza Nassiri; Mojtaba Tahmoorespur; Alireza Haghparast; Saeed Zibaee
Journal:  Adv Pharm Bull       Date:  2016-03-17

5.  Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies.

Authors:  Hong Zhang; Guangwen Wang; Jian Li; Yuchun Nie; Xuanling Shi; Gewei Lian; Wei Wang; Xiaolei Yin; Yang Zhao; Xiuxia Qu; Mingxiao Ding; Hongkui Deng
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

6.  Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein.

Authors:  Dong P Han; Hyung G Kim; Young B Kim; Leo L M Poon; Michael W Cho
Journal:  Virology       Date:  2004-08-15       Impact factor: 3.616

7.  SJL/J resistance to mouse hepatitis virus-JHM-induced neurologic disease can be partially overcome by viral variants of S and host immunosuppression.

Authors:  J M Pasick; G A Wilson; V L Morris; S Dales
Journal:  Microb Pathog       Date:  1992-07       Impact factor: 3.738

8.  Genomic Characterization and Phylogenetic Classification of Bovine Coronaviruses Through Whole Genome Sequence Analysis.

Authors:  Tohru Suzuki; Yoshihiro Otake; Satoko Uchimoto; Ayako Hasebe; Yusuke Goto
Journal:  Viruses       Date:  2020-02-06       Impact factor: 5.048
  8 in total

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