| Literature DB >> 16459060 |
Gorazd B Stokin1, Lawrence S B Goldstein.
Abstract
It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.Entities:
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Year: 2006 PMID： 16459060 DOI： 10.1016/j.jphysparis.2005.12.085
Source DB: PubMed Journal: J Physiol Paris ISSN： 0928-4257