| Literature DB >> 16459018 |
Cindie Courtin1, Dominique Crete, Corinne Canestrelli, Florence Noble, Cynthia Marie-Claire.
Abstract
It is well established that acute administration of psychostimulants alters dopamine transport. However, the exact mechanism of this modulation is still unknown. In this study we examined the mRNA levels of several proteins involved in the various proposed processes following cocaine administration. The expression levels of several immediate early genes were also studied. This was performed in rat striatum using real-time quantitative PCR. As expected, a marked increase of the immediate early genes Fos, Egr1 and Egr3 was observed. Egr2 was also found up-regulated. Among the different genes studied only Synaptotagmin4 in the SNARE family and Synphilin1 in the synaptic vesicles binding family were modulated by acute cocaine treatment. Interestingly, acute amphetamine treatment did not increase either Synaptotagmin4 and Synphilin1 mRNA levels, although increases in early genes expression were noted.Entities:
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Year: 2006 PMID： 16459018 PMCID： PMC1975760 DOI： 10.1016/j.neulet.2006.01.001
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046