| Literature DB >> 16458892 |
Iuliana Popa1, Dai Ishikawa, Michinori Tanaka, Koichi Ogino, Jacques Portoukalian, Takao Taki.
Abstract
GD3-replica peptides were obtained from a phage peptide library and an anti-GD3 monoclonal antibody (Mab) (4F6), and anti-GD3 Mabs were generated by immunizing a peptide GD3P4. A Mab, 3D2 was found to recognize GD3 by immunohistochemical approaches. Amino acid analysis of heavy and light chain variable regions of 4F6 and 3D2 showed that the respective chains had the same length, and only a few different amino acid substitutions were found. The present data indicate that the immunogenic GD3P4 is processed in a certain size and exposed on the antigen-presenting cells with a molecular shape quite similar to that of the GD3 epitope in 4F6.Entities:
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Year: 2006 PMID： 16458892 DOI： 10.1016/j.febslet.2006.01.063
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124