Literature DB >> 16458773

Osteoradionecrosis prevention myths.

Michael J Wahl1.   

Abstract

PURPOSE: To critically analyze controversial osteoradionecrosis (ORN) prevention techniques, including preradiation extractions of healthy or restorable teeth and the use of prophylactic antibiotics or hyperbaric oxygen (HBO) treatments for preradiation and postradiation extractions.
METHODS: The author reviewed ORN studies found on PubMed and in other article references, including studies on overall ORN incidence and pre- and postradiation incidence, with and without prophylactic HBO or antibiotics.
RESULTS: Owing in part to more efficient radiation techniques, the incidence of ORN has been declining in radiation patients over the last 2 decades, but the prevention of ORN remains controversial. A review of the available literature does not support the preradiation extraction of restorable or healthy teeth. There is also insufficient evidence to support the use of prophylactic HBO treatments or prophylactic antibiotics before extractions or other oral surgical procedures in radiation patients.
CONCLUSIONS: To prevent ORN, irradiated dental patients should maintain a high level of oral health. A preradiation referral for a dental evaluation and close collaboration by a multidisciplinary team can be invaluable for radiation patients. As with most other dental patients, restorable and healthy teeth should be retained in irradiated patients. The use of prophylactic HBO or antibiotics should be reconsidered for preradiation and postradiation extractions.

Entities:  

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Year:  2006        PMID: 16458773     DOI: 10.1016/j.ijrobp.2005.10.021

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN: 0360-3016            Impact factor:   7.038


  25 in total

1.  The impact of pre-radiotherapy dental extractions on head and neck cancer patients: a qualitative study.

Authors:  S Clough; M Burke; B Daly; S Scambler
Journal:  Br Dent J       Date:  2018-06-22       Impact factor: 1.626

2.  Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction.

Authors:  Satoshi Wanifuchi; Masaya Akashi; Yasuo Ejima; Hirotaka Shinomiya; Tsutomu Minamikawa; Shungo Furudoi; Naoki Otsuki; Ryohei Sasaki; Ken-Ichi Nibu; Takahide Komori
Journal:  Oral Maxillofac Surg       Date:  2016-07-11

3.  Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy.

Authors:  Mohamed El-Rabbany; Michael Duchnay; Hamid Reza Raziee; Maria Zych; Howard Tenenbaum; Prakeshkumar S Shah; Amir Azarpazhooh
Journal:  Cochrane Database Syst Rev       Date:  2019-11-20

Review 4.  Oral and dental late effects in survivors of childhood cancer: a Children's Oncology Group report.

Authors:  Karen E Effinger; Cesar A Migliorati; Melissa M Hudson; Kevin P McMullen; Sue C Kaste; Kathy Ruble; Gregory M T Guilcher; Ami J Shah; Sharon M Castellino
Journal:  Support Care Cancer       Date:  2014-04-30       Impact factor: 3.603

5.  Intensity-modulated proton therapy and osteoradionecrosis in oropharyngeal cancer.

Authors:  Wencheng Zhang; Xiaodong Zhang; Pei Yang; Pierre Blanchard; Adam S Garden; Brandon Gunn; C David Fuller; Mark Chambers; Katherine A Hutcheson; Rong Ye; Stephen Y Lai; Mohamed Abdallah Sherif Radwan; X Ron Zhu; Steven J Frank
Journal:  Radiother Oncol       Date:  2017-05-23       Impact factor: 6.280

6.  Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: likely contributions of both dental care and improved dose distributions.

Authors:  Merav A Ben-David; Maximiliano Diamante; Jeffrey D Radawski; Karen A Vineberg; Cynthia Stroup; Carol-Anne Murdoch-Kinch; Samuel R Zwetchkenbaum; Avraham Eisbruch
Journal:  Int J Radiat Oncol Biol Phys       Date:  2007-02-22       Impact factor: 7.038

7.  Tissue repair in osteoradionecrosis using pentoxifylline and tocopherol--report of three cases.

Authors:  Joslei Carlos Bohn; Juliana Lucena Schussel; Roberta Targa Stramandinoli-Zanicotti; Laurindo Moacir Sassi
Journal:  Oral Maxillofac Surg       Date:  2015-08-08

Review 8.  Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neck.

Authors:  C Ko; D Citrin
Journal:  Oral Dis       Date:  2008-11-11       Impact factor: 3.511

Review 9.  Osteoradionecrosis of the skull base.

Authors:  John P Leonetti; Jeffrey R Weishaar; David Gannon; Grant A Harmon; Alec Block; Douglas E Anderson
Journal:  J Neurooncol       Date:  2020-05-11       Impact factor: 4.130

10.  Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates.

Authors:  Ana O Hoff; Béla B Toth; Kadri Altundag; Marcella M Johnson; Carla L Warneke; Mimi Hu; Ajay Nooka; Gilbert Sayegh; Valentina Guarneri; Kimberly Desrouleaux; Jeffrey Cui; Andrea Adamus; Robert F Gagel; Gabriel N Hortobagyi
Journal:  J Bone Miner Res       Date:  2008-06       Impact factor: 6.741

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