PURPOSE: Malattia leventinese (ML) is an inherited macular degeneration characterized by the presence of large paracentral and small radial drusen. Our purpose was to describe optical coherent tomography (OCT) features observed in ML. DESIGN: Prospective observational case series. METHODS: Ten eyes from five patients with ML aged 27 to 44 years were prospectively included. Best-corrected visual acuity, fundus color photography of the retina, and OCT were performed in each patient. RESULTS: OCT revealed a hyperreflective thickening of the retinal pigment epithelium-Bruch membrane complex, associated with localized dome-shaped elevations. Retinal thickness above the drusen ranged from 221 to 292 microm (mean 260 microm). Foveal thickness ranged from 72 to 200 microm (mean 144 microm) CONCLUSIONS: The large paracentral drusen presented either as a thickening of the retinal pigment epithelium-Bruch complex or as local limited elevation of retinal pigment epithelium-Bruch complex, both associated with preservation of the neurosensory retina.
PURPOSE:Malattia leventinese (ML) is an inherited macular degeneration characterized by the presence of large paracentral and small radial drusen. Our purpose was to describe optical coherent tomography (OCT) features observed in ML. DESIGN: Prospective observational case series. METHODS: Ten eyes from five patients with ML aged 27 to 44 years were prospectively included. Best-corrected visual acuity, fundus color photography of the retina, and OCT were performed in each patient. RESULTS: OCT revealed a hyperreflective thickening of the retinal pigment epithelium-Bruch membrane complex, associated with localized dome-shaped elevations. Retinal thickness above the drusen ranged from 221 to 292 microm (mean 260 microm). Foveal thickness ranged from 72 to 200 microm (mean 144 microm) CONCLUSIONS: The large paracentral drusen presented either as a thickening of the retinal pigment epithelium-Bruch complex or as local limited elevation of retinal pigment epithelium-Bruch complex, both associated with preservation of the neurosensory retina.
Authors: Kamron N Khan; Shyamanga Borooah; Leonardo Lando; Kunny Dans; Omar A Mahroo; Amit Meshi; Angelos Kalitzeos; Georgios Agorogiannis; Sasan Moghimi; William R Freeman; Andrew R Webster; Anthony T Moore; Martin McKibbin; Michel Michaelides Journal: Transl Vis Sci Technol Date: 2020-05-23 Impact factor: 3.283
Authors: Nancy Gelvez; Paula Hurtado-Villa; Silvia Flórez; Anne Charlotte Brieke; Francisco Rodríguez; Ana María Bertolotto; Martha L Tamayo Journal: Biomedica Date: 2021-09-22 Impact factor: 0.935