PURPOSE: To evaluate regional cerebral blood flow (rCBF) in normal-tension glaucoma patients (NTGs) compared with normal volunteers (controls) in a pilot study. DESIGN: Observational cohort study. METHODS: The Iodine-123-IMP single photon emission computed tomography (SPECT) scans were acquired in 31 NTGs and 18 age-matched controls. The SPECT images in NTGs were classified and the quantitative rCBF data were compared with controls. RESULTS: Seven of 31 NTGs (22.6%) exhibited an Alzheimer's disease (AD)-like perfusion pattern although none of them were clinically diagnosed with AD. The visual field defect of NTGs with an AD-like pattern progressed more rapidly than NTGs with a normal pattern (P=.132). The rCBF in left parietal regions of NTGs with senile sclerotic or focal ischemic disk was significantly lower than controls (P<.05). CONCLUSIONS: A number of NTGs exhibited an AD-like perfusion pattern, suggesting that some of NTGs and AD patients might have a common pathologic mechanism.
PURPOSE: To evaluate regional cerebral blood flow (rCBF) in normal-tension glaucomapatients (NTGs) compared with normal volunteers (controls) in a pilot study. DESIGN: Observational cohort study. METHODS: The Iodine-123-IMP single photon emission computed tomography (SPECT) scans were acquired in 31 NTGs and 18 age-matched controls. The SPECT images in NTGs were classified and the quantitative rCBF data were compared with controls. RESULTS: Seven of 31 NTGs (22.6%) exhibited an Alzheimer's disease (AD)-like perfusion pattern although none of them were clinically diagnosed with AD. The visual field defect of NTGs with an AD-like pattern progressed more rapidly than NTGs with a normal pattern (P=.132). The rCBF in left parietal regions of NTGs with senile sclerotic or focal ischemic disk was significantly lower than controls (P<.05). CONCLUSIONS: A number of NTGs exhibited an AD-like perfusion pattern, suggesting that some of NTGs and ADpatients might have a common pathologic mechanism.
Authors: Robert O Duncan; Pamela A Sample; Christopher Bowd; Robert N Weinreb; Linda M Zangwill Journal: Vision Res Date: 2012-03-29 Impact factor: 1.886
Authors: Robert O Duncan; Pamela A Sample; Robert N Weinreb; Christopher Bowd; Linda M Zangwill Journal: Prog Retin Eye Res Date: 2006-11-27 Impact factor: 21.198
Authors: Alon Harris; Giovanna Guidoboni; Brent Siesky; Sunu Mathew; Alice C Verticchio Vercellin; Lucas Rowe; Julia Arciero Journal: Prog Retin Eye Res Date: 2020-01-24 Impact factor: 21.198