| Literature DB >> 16458429 |
Guanghui Wang1, Haifeng Chen, Minghui Huang, Naili Wang, Jinchao Zhang, Yaou Zhang, Ganrong Bai, Wang-Fun Fong, Mengsu Yang, Xinsheng Yao.
Abstract
Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin B1 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent.Entities:
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Year: 2006 PMID： 16458429 DOI： 10.1016/j.canlet.2005.10.050
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679