| Literature DB >> 16458083 |
Emma Vernersson1, Nelson K S Khoo, Maria L Henriksson, Göran Roos, Ruth H Palmer, Bengt Hallberg.
Abstract
Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, was first described as the fusion product causing a subtype of non-Hodgkin's lymphoma. To date Alk has been reported to be mainly expressed in CNS and other parts of the brain. Here we describe an extensive characterization of the mRNA and protein expression of ALK during mouse development. We show that mRNA and ALK protein show overlapping expressing patterns in specific regions of the central and the peripheral nervous systems. Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary.Entities:
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Year: 2006 PMID： 16458083 DOI： 10.1016/j.modgep.2005.11.006
Source DB: PubMed Journal: Gene Expr Patterns ISSN： 1567-133X Impact factor: 1.224